HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: NISCH (Q9Y2I1)
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Gene: NISCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 1504
+	Hs
		1081656 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		608203 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		385751 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		508279 FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665440 EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665370 EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		435807 IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		385155 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		S11IP_HUMAN (129-540): 2.54e-55: 213: 23.61
+	Hs
		385127 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		CEP97_HUMAN (221-554): 1.17e-54: 209: 25.85
+	Gm
		1341216 CLV1B_SOYBN (3-809): 4.92e-169: 516: 12.21		CLV1B_SOYBN (344-664): 1.49e-31: 136: 11.89
+	Hs
		385122 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	Hs
		1049964 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		607966 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		385131 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		LRC8A_HUMAN (209-418): 2.58e-21: 103: 21.82
+	Hs
		665407 EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	Hs
		385441 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		LRRC1_HUMAN (202-471): 1.35e-19: 96.3: 21.22
+	Hs
		384823 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		507995 FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		384750 NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85		FLII_HUMAN (198-387): 6.39e-13: 76.3: 17.81
+	Hs
		435639 IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01