HitPredict

Interactor 1: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Interactor 2: SYTL4 (Q96C24)
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
Gene: SYTL4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	12590134, 12101244
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C2~SNARE, C2~Syntaxin
Common GO terms	GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0006887 - exocytosis GO:0030073 - insulin secretion
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 288 Hs			1 671
+	Hs
		699277 STX2_HUMAN (1-288): 6.6e-82: 250: 63.89		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Hs
		1030179 STX3_HUMAN (1-288): 2.81e-64: 205: 62.41		SYTL4_HUMAN (1-671): 0: 587: 100.00
+	Dm
		599152 STX1A_DROME (2-287): 2.6e-75: 233: 69.90		SY65_DROME (175-654): 1.88e-82: 270: 22.00
+	Mm
		192842 STX1A_MOUSE (1-288): 3.69e-86: 261: 98.26		SYT2_MOUSE (215-493): 2.34e-30: 126: 16.49
+	Rn
		699170 STX1A_RAT (1-288): 3.03e-86: 261: 98.61		RP3A_RAT (518-671): 1.13e-28: 123: 22.49
+	Rn
		600312 STX1A_RAT (1-288): 3.03e-86: 261: 98.61		SYT1_RAT (513-666): 5.95e-29: 121: 27.22
+	Hs
		599575 STX1A_HUMAN (1-288): 1.66e-84: 256: 100.00		SYT1_HUMAN (513-666): 6.03e-29: 121: 27.22
+	Hs
		599551 STX2_HUMAN (1-288): 6.6e-82: 250: 63.89		SYT1_HUMAN (513-666): 6.03e-29: 121: 27.22
+	Dm
		1098093 STX1A_DROME (2-287): 2.6e-75: 233: 69.90		Q9U6P7_DROME (502-665): 1.34e-21: 100: 20.67
+	Hs
		599569 STX3_HUMAN (1-288): 2.81e-64: 205: 62.41		SYT1_HUMAN (513-666): 6.03e-29: 121: 27.22
+	Hs
		599566 STX4_HUMAN (1-287): 1.22e-63: 203: 43.58		SYT1_HUMAN (513-666): 6.03e-29: 121: 27.22