HitPredict

Interactor 1: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Interactor 2: SNAB (Q9H115)
Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta)
Gene: NAPB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	32296183, 24722188, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNAP~SNARE, SNAP~Syntaxin
Common GO terms	GO:0006886 - intracellular protein transport GO:0010807 - regulation of synaptic vesicle priming GO:0070044 - synaptobrevin 2-SNAP-25-syntaxin-1a complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 298
+	Hs
		898845 STX1B_HUMAN (1-288): 5.2e-85: 258: 83.33		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		699286 STX2_HUMAN (1-288): 6.6e-82: 250: 63.89		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Mm
		192858 STX1A_MOUSE (1-288): 3.69e-86: 261: 98.26		SNAA_MOUSE (1-293): 4.83e-109: 319: 83.62
+	Rn
		699171 STX1A_RAT (1-288): 3.03e-86: 261: 98.61		SNAA_RAT (1-293): 2.2e-108: 318: 82.94
+	Hs
		873547 STX1A_HUMAN (1-288): 1.66e-84: 256: 100.00		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		1328433 X5D7S1_HUMAN (1-286): 4.44e-66: 208: 85.66		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		1030185 STX3_HUMAN (1-288): 2.81e-64: 205: 62.41		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		1017786 STX4_HUMAN (1-287): 1.22e-63: 203: 43.58		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Dm
		1095554 STX1A_DROME (2-287): 2.6e-75: 233: 69.90		SNAP_DROME (5-292): 1.02e-103: 306: 62.15
+	Hs
		873540 STX3_HUMAN (1-288): 2.81e-64: 205: 62.41		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		873535 STX4_HUMAN (1-287): 1.22e-63: 203: 43.58		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		1205369 STX12_HUMAN (26-271): 2.32e-51: 171: 24.50		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		269400 STX11_HUMAN (1-274): 2.87e-54: 179: 29.72		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		873559 STX12_HUMAN (26-271): 2.32e-51: 171: 24.50		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Dm
		1095553 STX5_DROME (2-268): 2.15e-51: 176: 16.61		SNAP_DROME (5-292): 1.02e-103: 306: 62.15
+	Dm
		1098094 STX1A_DROME (2-287): 2.6e-75: 233: 69.90		Q9U6R9_DROME (4-265): 3.27e-59: 193: 19.70
+	Dm
		1098102 STX1A_DROME (2-287): 2.6e-75: 233: 69.90		Q9VH25_DROME (42-265): 8.61e-52: 173: 19.03
+	Hs
		1205360 STX12_HUMAN (26-271): 2.32e-51: 171: 24.50		SNAG_HUMAN (4-251): 6.3e-69: 218: 24.30
+	Dm
		1097999 STX5_DROME (2-268): 2.15e-51: 176: 16.61		Q9U6R9_DROME (4-265): 3.27e-59: 193: 19.70
+	Dm
		1098003 STX5_DROME (2-268): 2.15e-51: 176: 16.61		Q9VH25_DROME (42-265): 8.61e-52: 173: 19.03