HitPredict

Interactor 1: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	33961781, 23602568
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, direct interaction, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008380 - RNA splicing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 238 Hs			1 655
+	Hs
		1263452 SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		942811 RB15B_HUMAN (4-232): 1.77e-31: 123: 22.41		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		942687 SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		942840 SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		853855 NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Sp
		737030 PPIL4_SCHPO (1-184): 8.1e-26: 106: 20.11		DSK1_SCHPO (54-235): 1.53e-78: 261: 50.27
+	Hs
		833887 SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00		CLK2_HUMAN (484-653): 2.41e-63: 220: 29.07
+	Hs
		833938 SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60		CLK2_HUMAN (484-653): 2.41e-63: 220: 29.07
+	Hs
		625466 SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		834053 SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65
+	Hs
		834087 SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65
+	At
		51039 RSZ33_ARATH (1-229): 5.07e-28: 109: 34.18		A1L4Y9_ARATH (488-655): 1.21e-61: 212: 28.09
+	At
		847177 RSZ33_ARATH (1-229): 5.07e-28: 109: 34.18		AFC3_ARATH (488-655): 1.21e-61: 212: 28.09
+	Hs
		833742 SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00		CLK1_HUMAN (436-654): 8.6e-61: 212: 23.45
+	Hs
		833788 SRS12_HUMAN (1-218): 8.5e-28: 108: 32.60		CLK1_HUMAN (436-654): 8.6e-61: 212: 23.45
+	Hs
		853953 NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42		DYRK2_HUMAN (483-654): 8.53e-63: 220: 32.47
+	Hs
		432604 HNRPC_HUMAN (3-186): 3e-24: 99: 22.58		CLK2_HUMAN (484-653): 2.41e-63: 220: 29.07
+	Hs
		432550 HNRPC_HUMAN (3-186): 3e-24: 99: 22.58		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	At
		286430 RSZ21_ARATH (11-212): 1.3e-26: 103: 37.13		AFC3_ARATH (488-655): 1.21e-61: 212: 28.09
+	Hs
		432605 HNRPC_HUMAN (3-186): 3e-24: 99: 22.58		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65