HitPredict

Interactor 1: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27684187, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pro_isomerase~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 238 Hs			1 301
+	Hs
		432996 HNRPC_HUMAN (3-186): 3e-24: 99: 22.58		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		952176 SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		516744 PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	At
		1340387 SR30_ARATH (10-89): 1.74e-23: 96.9: 48.78		CYP63_ARATH (134-299): 1.18e-89: 279: 58.62
+	Hs
		614281 NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42		PPIB_HUMAN (143-300): 5.03e-63: 199: 58.49
+	Hs
		432637 HNRPC_HUMAN (3-186): 3e-24: 99: 22.58		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Hs
		923771 RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46