HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: RBBP6 (Q7Z6E9)
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)
Gene: RBBP6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	32460013, 28514442, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 1792
+	Hs
		1056844 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37
+	Hs
		230368 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		ZC3H1_HUMAN (679-1650): 2.57e-10: 68: 12.68
+	Mm
		1150289 SMCA2_MOUSE (137-551): 5.16e-46: 175: 14.44		SRRM2_MOUSE (83-779): 3.79e-09: 64.2: 10.47
+	Hs
		1031405 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		TITIN_HUMAN (79-1153): 3.14e-15: 84.6: 10.07
+	Hs
		516595 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		KMT2C_HUMAN (88-1775): 2.2e-16: 88.1: 7.78
+	Hs
		230351 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		ZC3H1_HUMAN (679-1650): 2.57e-10: 68: 12.68
+	Sc
		376722 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		MPE1_YEAST (2-378): 3.83e-29: 125: 26.03
+	Hs
		516609 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		TITIN_HUMAN (79-1153): 3.14e-15: 84.6: 10.07
+	Dm
		113976 M9PB30_DROME (190-412): 1.36e-12: 73: 16.67		M9PB30_DROME (259-1062): 5.51e-26: 120: 9.10
+	Hs
		516766 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PRC2C_HUMAN (87-1452): 1.6e-12: 75.4: 8.27
+	Hs
		965152 PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56		ANK2_HUMAN (331-1734): 6.96e-13: 76.5: 11.90
+	Hs
		1056974 WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69		MDC1_HUMAN (508-1516): 4.61e-24: 113: 10.37
+	Mm
		1351630 PCLO_MOUSE (195-468): 6.01e-14: 77.6: 11.31		PCLO_MOUSE (276-1782): 2.57e-09: 65: 8.17
+	Mm
		1111946 SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30		SRRM2_MOUSE (83-779): 3.79e-09: 64.2: 10.47