HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36373674
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:0035061 - interchromatin granule
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 1101
+	Hs
		1221566 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		847011 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1031385 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		516583 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221731 PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221692 DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221717 WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Sc
		376836 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		SMC3_YEAST (51-1055): 7.78e-71: 260: 13.66