HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: PSPC1 (Q8WXF1)
Paraspeckle component 1 (Paraspeckle protein 1)
Gene: PSPC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck and 1 others more... GO:0042382 - paraspeckles
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 523
+	Mm
		1156796 CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62		NONO_MOUSE (45-523): 1.13e-66: 224: 57.83
+	Hs
		1235754 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		PSPC1_HUMAN (1-523): 7.74e-85: 273: 100.00
+	Hs
		846779 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		1069746 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Hs
		1031404 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PSPC1_HUMAN (1-523): 7.74e-85: 273: 100.00
+	Hs
		846978 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		NONO_HUMAN (50-523): 4.22e-68: 228: 57.60
+	Mm
		1150292 SMCA2_MOUSE (137-551): 5.16e-46: 175: 14.44		NONO_MOUSE (45-523): 1.13e-66: 224: 57.83
+	Hs
		613386 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Mm
		1150291 SMCA2_MOUSE (137-551): 5.16e-46: 175: 14.44		SFPQ_MOUSE (53-523): 2.17e-59: 210: 53.93
+	Hs
		613519 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		SFPQ_HUMAN (53-523): 3.05e-59: 210: 54.14
+	Hs
		1077379 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		516495 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PABP1_HUMAN (4-522): 4.65e-70: 237: 14.16
+	Hs
		1084591 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		RBM4B_HUMAN (83-190): 4.07e-09: 60.5: 33.04
+	Mm
		1156792 CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62		RBM4_MOUSE (83-190): 3.35e-09: 60.5: 33.04
+	Hs
		1084602 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		RBM4_HUMAN (83-190): 4.98e-09: 60.1: 32.14
+	Zm
		8143 A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55		A0A1D6ELH4_MAIZE (4-416): 2.94e-44: 167: 14.29
+	Hs
		1077418 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11
+	Hs
		474021 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PAB4L_HUMAN (147-425): 7.96e-26: 110: 13.89
+	Hs
		1020249 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		ELAV2_HUMAN (84-156): 1.29e-13: 74.1: 31.65
+	Hs
		1031344 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		ELAV1_HUMAN (84-156): 3.1e-13: 72.6: 29.11