HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 530
+	Hs
		369698 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		846832 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1235756 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369213 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370006 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369214 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		587141 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		782503 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377191 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		782504 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377192 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		611401 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		611466 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		795589 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30
+	Hs
		611402 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		795590 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30
+	Hs
		487481 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487246 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487592 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487247 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59