HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: DIDO1 (Q9BTC0)
Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)
Gene: DIDO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 2240
+	Hs
		832991 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		YLPM1_HUMAN (1365-2223): 2.36e-41: 170: 13.66
+	Hs
		1084612 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		NSRP1_HUMAN (2033-2240): 4.74e-23: 108: 18.27
+	Hs
		1084668 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		SRRM2_HUMAN (6-1279): 6.35e-14: 80.3: 8.36
+	Hs
		1084551 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		PHF3_HUMAN (1921-2190): 3.11e-09: 64.7: 14.29
+	Hs
		846886 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		CXXC1_HUMAN (245-393): 2.59e-34: 144: 26.75
+	Hs
		516766 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PRC2C_HUMAN (27-1904): 3.9e-50: 199: 9.83
+	Hs
		832977 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		YLPM1_HUMAN (1365-2223): 2.36e-41: 170: 13.66
+	Mm
		1150289 SMCA2_MOUSE (137-551): 5.16e-46: 175: 14.44		SRRM2_MOUSE (341-2148): 4.18e-24: 113: 8.47
+	Hs
		1235797 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		NSRP1_HUMAN (2033-2240): 4.74e-23: 108: 18.27
+	Hs
		847058 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		CIC_HUMAN (2-1657): 2.53e-13: 78.4: 7.87
+	Hs
		1031405 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		TITIN_HUMAN (19-1290): 3.32e-21: 104: 10.49
+	Hs
		516609 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		TITIN_HUMAN (19-1290): 3.32e-21: 104: 10.49
+	Hs
		302269 SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25		SC24C_HUMAN (1537-1898): 1.52e-16: 88.6: 19.74
+	Hs
		516595 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		KMT2C_HUMAN (268-1949): 7.95e-19: 96.6: 10.24
+	Hs
		516749 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		SRRM2_HUMAN (6-1279): 6.35e-14: 80.3: 8.36
+	Mm
		1111946 SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30		SRRM2_MOUSE (341-2148): 4.18e-24: 113: 8.47
+	Hs
		867103 TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18		SC24C_HUMAN (1537-1898): 1.52e-16: 88.6: 19.74
+	Hs
		867119 SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05		CIC_HUMAN (2-1657): 2.53e-13: 78.4: 7.87
+	Mm
		1351630 PCLO_MOUSE (195-468): 6.01e-14: 77.6: 11.31		PCLO_MOUSE (27-2002): 2.58e-11: 71.8: 9.25
+	Dm
		113976 M9PB30_DROME (190-412): 1.36e-12: 73: 16.67		M9PB30_DROME (42-789): 3.1e-10: 68.3: 8.80