HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: RBM4 (Q9BWF3)
RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)
Gene: RBM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 364
+	Mm
		1156792 CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62		RBM4_MOUSE (1-364): 1.95e-96: 292: 93.43
+	Hs
		1084591 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		RBM4B_HUMAN (1-364): 1.52e-90: 277: 87.36
+	Hs
		516674 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		RBM4_HUMAN (1-364): 5.04e-101: 304: 100.00
+	Mm
		857339 CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62		TIA1_MOUSE (77-253): 1.67e-16: 81.7: 13.04
+	Hs
		1084558 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		CELF1_HUMAN (2-111): 1.04e-12: 70.9: 30.95
+	Hs
		1235776 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		RBM14_HUMAN (2-339): 3.33e-48: 174: 28.30
+	Hs
		1235759 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		CELF1_HUMAN (2-111): 1.04e-12: 70.9: 30.95
+	Hs
		474021 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PAB4L_HUMAN (69-238): 2.44e-17: 84.1: 15.17
+	Hs
		516495 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PABP1_HUMAN (68-249): 1.02e-15: 80.2: 13.68
+	Hs
		1031413 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		CELF1_HUMAN (2-111): 1.04e-12: 70.9: 30.95
+	Hs
		1020249 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		ELAV2_HUMAN (4-76): 1.91e-12: 69.4: 25.93
+	Hs
		516635 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PABP5_HUMAN (82-252): 1.03e-16: 82.5: 16.76
+	Mm
		665745 PABP1_MOUSE (81-518): 3.65e-24: 108: 16.63		TIA1_MOUSE (77-253): 1.67e-16: 81.7: 13.04
+	Hs
		516339 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PABP1_HUMAN (68-249): 1.02e-15: 80.2: 13.68
+	Hs
		516471 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		TIAR_HUMAN (70-253): 2.99e-15: 78.3: 12.57
+	Zm
		8143 A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55		A0A1D6ELH4_MAIZE (49-252): 9e-13: 71.3: 12.26
+	Hs
		516621 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		CELF1_HUMAN (2-111): 1.04e-12: 70.9: 30.95
+	Hs
		516484 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		ELAV2_HUMAN (4-76): 1.91e-12: 69.4: 25.93
+	Hs
		516689 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PABP3_HUMAN (1-270): 1.87e-11: 67.5: 14.44