HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: DDX20 (Q9UHI6)
Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3)
Gene: DDX20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 824
+	Hs
		1235830 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		DDX20_HUMAN (1-824): 0: 727: 100.00
+	Hs
		1084557 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DDX17_HUMAN (13-501): 5.11e-135: 420: 23.99
+	Hs
		1084519 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DDX42_HUMAN (9-756): 3.7e-132: 418: 17.75
+	Hs
		571475 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DDX5_HUMAN (13-488): 1.13e-131: 407: 22.70
+	Hs
		757633 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		IF4A3_HUMAN (38-444): 2.03e-124: 381: 32.84
+	Hs
		640464 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		DDX6_HUMAN (25-444): 7.61e-164: 486: 32.62
+	Hs
		516363 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		DDX6_HUMAN (25-444): 7.61e-164: 486: 32.62
+	Hs
		1204671 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		DDX42_HUMAN (9-756): 3.7e-132: 418: 17.75
+	Hs
		640620 PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56		DDX6_HUMAN (25-444): 7.61e-164: 486: 32.62
+	Hs
		571365 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		DDX5_HUMAN (13-488): 1.13e-131: 407: 22.70
+	Dm
		597046 PABP_DROME (81-169): 1.2e-18: 91.5: 24.44		DDX6_DROME (46-444): 3.45e-163: 483: 33.50
+	Sc
		376792 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		DHH1_YEAST (37-450): 3.88e-165: 490: 35.73
+	Hs
		1046056 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DX39B_HUMAN (64-440): 3.19e-67: 231: 36.05
+	Hs
		117150 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		DX39A_HUMAN (64-440): 1.21e-66: 229: 35.43
+	Hs
		516391 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		IF4A3_HUMAN (38-444): 2.03e-124: 381: 32.84
+	Mm
		1111932 SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30		DDX5_MOUSE (13-488): 2.28e-132: 409: 22.70
+	Hs
		1031321 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		DX39B_HUMAN (64-440): 3.19e-67: 231: 36.05
+	Hs
		1031325 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		IF4A2_HUMAN (63-424): 6.57e-66: 227: 38.74
+	Hs
		516509 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		DX39B_HUMAN (64-440): 3.19e-67: 231: 36.05
+	Hs
		516515 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		IF4A2_HUMAN (63-424): 6.57e-66: 227: 38.74