HitPredict

Interactor 1: MK06 (Q16659)
Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)
Gene: MAPK6

Interactor 2: WDR6 (Q9NNW5)
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
Gene: WDR6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26972000
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 721 Hs			1 1121
+	Hs
		929482 MK06_HUMAN (1-721): 0: 638: 100.00		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		1085552 MK06_HUMAN (1-721): 0: 638: 100.00		FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41
+	Rn
		600376 MK03_RAT (10-362): 7.43e-133: 399: 41.13		RACK1_RAT (196-523): 2.91e-47: 173: 17.21
+	Hs
		625337 CDK2_HUMAN (17-322): 1.11e-133: 398: 31.19		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		929479 MK14_HUMAN (4-370): 4.78e-128: 386: 33.51		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		659095 MK01_HUMAN (8-354): 5.92e-137: 408: 41.83		FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41
+	Hs
		254043 CDK2_HUMAN (17-322): 1.11e-133: 398: 31.19		WDR1_HUMAN (538-1119): 1.07e-31: 134: 9.41
+	Hs
		1082658 MK14_HUMAN (4-370): 4.78e-128: 386: 33.51		FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41
+	Dm
		186181 MK38B_DROME (1-354): 5.56e-122: 370: 33.33		GBLP_DROME (252-508): 8.1e-28: 117: 16.11
+	Hs
		647634 MK03_HUMAN (8-360): 7.75e-133: 399: 41.41		GEMI5_HUMAN (758-1120): 9.39e-16: 85.1: 9.37
+	At
		1106372 MPK4_ARATH (14-363): 1.41e-134: 403: 38.59		LST81_ARATH (137-308): 8.15e-13: 72.5: 22.16
+	Hs
		647650 MK03_HUMAN (8-360): 7.75e-133: 399: 41.41		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Hs
		625543 CDK2_HUMAN (17-322): 1.11e-133: 398: 31.19		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Hs
		658879 MK01_HUMAN (8-354): 5.92e-137: 408: 41.83		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	At
		189012 MPK3_ARATH (3-354): 4.59e-131: 394: 38.38		GBLPA_ARATH (88-239): 1.98e-11: 68.8: 9.43
+	At
		189013 MPK6_ARATH (3-364): 2.62e-130: 393: 37.71		GBLPA_ARATH (88-239): 1.98e-11: 68.8: 9.43
+	At
		1106243 MPK3_ARATH (3-354): 4.59e-131: 394: 38.38		GPLPC_ARATH (37-239): 6.59e-11: 66.8: 10.43
+	At
		1106623 MPK6_ARATH (3-364): 2.62e-130: 393: 37.71		GPLPC_ARATH (37-239): 6.59e-11: 66.8: 10.43
+	At
		1106202 MPK3_ARATH (3-354): 4.59e-131: 394: 38.38		GPLPB_ARATH (357-532): 5.44e-09: 61.1: 10.00
+	At
		1106574 MPK6_ARATH (3-364): 2.62e-130: 393: 37.71		GPLPB_ARATH (357-532): 5.44e-09: 61.1: 10.00