HitPredict

Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Interactor 2: X5DP31 (X5DP31)
Aryl-hydrocarbon receptor nuclear translocator 2 isoform E
Gene: ARNT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS~PAS_3, PAS_11~PAS_3
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 826 Hs			1 660
+	Hs
		1085690 HIF1A_HUMAN (1-826): 0: 741: 100.00		ARNT2_HUMAN (1-658): 0: 631: 89.88
+	Hs
		649123 HIF1A_HUMAN (1-826): 0: 741: 100.00		ARNT_HUMAN (4-658): 0: 545: 52.40
+	Mm
		864794 HIF1A_MOUSE (1-826): 0: 706: 87.63		ARNT_MOUSE (4-658): 0: 542: 53.35
+	Hs
		126132 HIF1A_HUMAN (1-826): 0: 741: 100.00		BMAL1_HUMAN (15-593): 2.35e-166: 492: 30.31
+	Hs
		87730 D0VY79_HUMAN (1-826): 0: 741: 100.00		BMAL1_HUMAN (15-593): 2.35e-166: 492: 30.31
+	Mm
		1142409 HIF1A_MOUSE (1-826): 0: 706: 87.63		BMAL1_MOUSE (15-593): 5.34e-166: 491: 29.97
+	Hs
		1306541 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		ARNT2_HUMAN (1-658): 0: 631: 89.88
+	Hs
		1085655 HIF1A_HUMAN (1-826): 0: 741: 100.00		EPAS1_HUMAN (50-658): 2.53e-127: 398: 20.32
+	Hs
		1085577 HIF1A_HUMAN (1-826): 0: 741: 100.00		HIF1A_HUMAN (48-604): 2.8e-127: 397: 20.46
+	Hs
		1085730 HIF1A_HUMAN (1-826): 0: 741: 100.00		HIF3A_HUMAN (50-647): 5.8e-117: 366: 18.70
+	Mm
		1012216 HIF1A_MOUSE (1-826): 0: 706: 87.63		HIF3A_MOUSE (52-654): 3.12e-114: 358: 19.23
+	Hs
		649150 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		ARNT_HUMAN (4-658): 0: 545: 52.40
+	Mm
		864790 EPAS1_MOUSE (4-824): 5.43e-165: 503: 40.91		ARNT_MOUSE (4-658): 0: 542: 53.35
+	Hs
		126166 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		BMAL1_HUMAN (15-593): 2.35e-166: 492: 30.31
+	Mm
		956582 EPAS1_MOUSE (4-824): 5.43e-165: 503: 40.91		BMAL1_MOUSE (15-593): 5.34e-166: 491: 29.97
+	Hs
		1264408 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		BMAL2_HUMAN (48-551): 2.11e-146: 441: 32.35
+	Hs
		1306527 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		EPAS1_HUMAN (50-658): 2.53e-127: 398: 20.32
+	Hs
		1306557 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		HIF3A_HUMAN (50-647): 5.8e-117: 366: 18.70
+	Mm
		956580 EPAS1_MOUSE (4-824): 5.43e-165: 503: 40.91		HIF3A_MOUSE (52-654): 3.12e-114: 358: 19.23