HitPredict

Interactor 1: IF16 (Q16666)
Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)
Gene: IFI16

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

The method score is based on:

Property	Details
Experiments	26121674, 27764250, 21575908
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PYRIN~PYRIN
Common GO terms	GO:0002218 - activation of innate immune response GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm and 7 others more... GO:0005829 - cytosol GO:0010506 - regulation of autophagy GO:0032731 - positive regulation of interleukin-1 beta production GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0045087 - innate immune response GO:0051607 - defense response to virus GO:0072332 - intrinsic apoptotic signaling pathway by p53 class mediator
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	785
Hs

1	195

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024