HitPredict

Interactor 1: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	20663916, 21554500, 20593489, 29340707
Identification Methods	enzymatic study, protein kinase assay, anti bait coimmunoprecipitation
Interaction Type	direct interaction, phosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 344
+	Hs
		682163 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		AKT2_HUMAN (3-343): 1.2e-140: 408: 26.91
+	Hs
		935110 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Mm
		250432 H33_MOUSE (1-136): 4.53e-61: 185: 93.38		AURKB_MOUSE (1-340): 4.11e-136: 392: 83.19
+	Hs
		952545 H33_HUMAN (1-136): 4.53e-61: 185: 93.38		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		1174628 H32_HUMAN (1-136): 1.34e-60: 184: 96.32		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Mm
		952738 H33_MOUSE (1-136): 4.53e-61: 185: 93.38		AURKA_MOUSE (4-334): 6.51e-135: 390: 61.86
+	Hs
		160506 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		160599 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		610712 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Hs
		610715 H33_HUMAN (1-136): 4.53e-61: 185: 93.38		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Hs
		935379 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		AURKC_HUMAN (35-337): 4.3e-133: 383: 75.91
+	Hs
		1157219 H3C_HUMAN (1-136): 2.16e-58: 178: 90.44		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		610742 H32_HUMAN (1-136): 1.34e-60: 184: 96.32		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Dm
		356080 H3_DROME (1-136): 1.34e-60: 184: 96.32		Q27393_DROME (8-332): 1.02e-131: 384: 51.99
+	At
		886668 H31_ARATH (1-136): 3.02e-60: 183: 94.12		AUR1_ARATH (49-331): 2.44e-128: 370: 61.75
+	Hs
		828344 CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		828423 CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24		AURKC_HUMAN (35-337): 4.3e-133: 383: 75.91
+	Dm
		356113 H3_DROME (1-136): 1.34e-60: 184: 96.32		AURKB_DROME (76-329): 4.8e-94: 284: 52.34
+	Sc
		758807 H3_YEAST (1-136): 1.43e-55: 171: 86.03		IPL1_YEAST (9-330): 1.16e-79: 249: 41.95
+	Sc
		730798 CENPA_YEAST (18-134): 1.65e-41: 139: 53.33		IPL1_YEAST (9-330): 1.16e-79: 249: 41.95