HitPredict

Interactor 1: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24412544
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 2696
+	Hs
		935129 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		203659 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		SUV91_HUMAN (1705-2081): 6.86e-87: 293: 21.86
+	Hs
		935237 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		SUV92_HUMAN (1702-2082): 6.86e-81: 275: 21.96
+	Hs
		331780 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		331823 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		935251 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		1086320 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		935204 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Hs
		1086306 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Hs
		935126 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		935276 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		ASH1L_HUMAN (1243-2111): 4.6e-62: 239: 17.33
+	Hs
		1086279 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		935205 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		1086307 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		934804 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		1079993 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		935004 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		1086228 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152625 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69
+	Mm
		101827 H33_MOUSE (1-136): 4.53e-61: 185: 93.38		F8WI37_MOUSE (2088-2261): 1.86e-09: 66.2: 13.59