HitPredict

Interactor 1: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	30021884, 37071682
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 129 Hs			1 126
+	Hs
		617950 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1O_HUMAN (1-126): 2.36e-55: 170: 99.21
+	Hs
		1087007 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		617974 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		H2B1O_HUMAN (1-126): 2.36e-55: 170: 99.21
+	Hs
		1087239 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		1087377 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		1216239 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00
+	Hs
		707681 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		886117 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		918497 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		1087366 H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		1274408 H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00
+	Hs
		886151 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		886186 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		241623 H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		883049 H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06		H2BFS_HUMAN (1-126): 1.16e-54: 168: 96.83
+	Hs
		1087049 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B3B_HUMAN (1-126): 1.45e-52: 163: 96.03
+	Hs
		1216224 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B3B_HUMAN (1-126): 1.45e-52: 163: 96.03
+	Hs
		1087076 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1A_HUMAN (1-126): 1.15e-47: 151: 84.25
+	Hs
		1216241 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1A_HUMAN (1-126): 1.15e-47: 151: 84.25
+	Hs
		1150515 H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06		H2B2C_HUMAN (1-96): 1.36e-44: 145: 89.58