HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 336
+	Hs
		918631 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		707723 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1231231 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		918311 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		707600 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		1087375 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		918649 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		717646 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		717877 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		707534 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		717607 H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		718401 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		1087364 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		918638 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		707725 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		749336 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		749545 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		707539 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		551445 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		RAG1_HUMAN (42-197): 1.72e-29: 121: 20.51