HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: TCF20 (Q9UGU0)
Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)
Gene: TCF20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	35271311, 22081970
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 1960
+	Hs
		918756 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		TCF20_HUMAN (1-1960): 0: 925: 100.00
+	Hs
		1087223 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		RAI1_HUMAN (1-1933): 2.26e-103: 371: 20.28
+	Hs
		1191020 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		RAI1_HUMAN (1-1933): 2.26e-103: 371: 20.28
+	Hs
		918475 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		RAI1_HUMAN (1-1933): 2.26e-103: 371: 20.28
+	Hs
		707670 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		RAI1_HUMAN (1-1933): 2.26e-103: 371: 20.28
+	Hs
		1087483 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		KMT2B_HUMAN (1766-1932): 1.68e-35: 151: 19.05
+	Hs
		918772 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		KMT2B_HUMAN (1766-1932): 1.68e-35: 151: 19.05
+	Hs
		918303 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		KMT2A_HUMAN (1765-1933): 1.16e-32: 142: 20.00
+	Hs
		975269 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		KMT2A_HUMAN (1765-1933): 1.16e-32: 142: 20.00
+	Hs
		707596 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		KMT2A_HUMAN (1765-1933): 1.16e-32: 142: 20.00
+	Hs
		918501 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		PHF6_HUMAN (1814-1946): 5.25e-24: 108: 21.38
+	Hs
		707682 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		PHF6_HUMAN (1814-1946): 5.25e-24: 108: 21.38
+	Hs
		1129830 H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62		TITIN_HUMAN (744-1529): 2.73e-10: 68.4: 11.54
+	Hs
		617962 H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21		TITIN_HUMAN (744-1529): 2.73e-10: 68.4: 11.54
+	Hs
		1087299 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		TITIN_HUMAN (744-1529): 2.73e-10: 68.4: 11.54
+	Hs
		1264778 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		TITIN_HUMAN (744-1529): 2.73e-10: 68.4: 11.54
+	Hs
		883041 H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83		TITIN_HUMAN (744-1529): 2.73e-10: 68.4: 11.54
+	Hs
		918561 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		TITIN_HUMAN (744-1529): 2.73e-10: 68.4: 11.54
+	Hs
		918533 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		KMT2C_HUMAN (307-902): 2.88e-09: 64.9: 11.15
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99