HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: UBP22 (Q9UPT9)
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)
Gene: USP22

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21746879
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 525
+	Hs
		707794 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP22_HUMAN (1-525): 0: 549: 100.00
+	Hs
		707665 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP51_HUMAN (12-523): 4.98e-164: 483: 68.69
+	Hs
		918801 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		UBP3_HUMAN (38-517): 1.81e-112: 345: 26.13
+	Hs
		707807 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP3_HUMAN (38-517): 1.81e-112: 345: 26.13
+	Hs
		1087411 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP42_HUMAN (153-520): 5.41e-100: 330: 27.37
+	Hs
		777048 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP8_HUMAN (116-517): 3.79e-99: 325: 28.14
+	Hs
		420891 H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21		UBP36_HUMAN (125-519): 4.11e-98: 322: 24.24
+	Hs
		241654 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		UBP36_HUMAN (125-519): 4.11e-98: 322: 24.24
+	Hs
		707772 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP36_HUMAN (125-519): 4.11e-98: 322: 24.24
+	Hs
		271037 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP2_HUMAN (150-518): 1.04e-100: 317: 30.46
+	Hs
		707785 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP21_HUMAN (174-518): 1.8e-94: 300: 27.42
+	Hs
		1121182 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		UBP39_HUMAN (14-524): 1.9e-93: 297: 16.61
+	Hs
		918411 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		UBP39_HUMAN (14-524): 1.9e-93: 297: 16.61
+	Sc
		355943 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		UBP8_YEAST (20-522): 7.56e-109: 334: 28.14
+	Sc
		355547 H2B1_YEAST (3-125): 1.81e-36: 122: 71.55		UBP8_YEAST (20-522): 7.56e-109: 334: 28.14
+	Hs
		259286 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP12_HUMAN (155-521): 6.15e-90: 282: 25.44
+	Hs
		905383 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP46_HUMAN (155-521): 9.16e-89: 278: 25.44
+	Hs
		905394 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		UBP46_HUMAN (155-521): 9.16e-89: 278: 25.44