HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: PARP3 (Q9Y6F1)
Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
Gene: PARP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 533
+	Hs
		1087460 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		918755 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		707781 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		1231259 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		455094 H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		455301 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		455500 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		455733 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		455136 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		455276 H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		1282979 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		455645 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		455738 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Dm
		355257 H2B_DROME (36-126): 9.49e-47: 148: 95.60		PARP_DROME (14-533): 2.05e-168: 504: 31.04
+	Hs
		617984 H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21		PARP4_HUMAN (117-533): 1.12e-79: 274: 21.08
+	Hs
		1274474 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		PARP4_HUMAN (117-533): 1.12e-79: 274: 21.08
+	Hs
		241659 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		PARP4_HUMAN (117-533): 1.12e-79: 274: 21.08
+	Hs
		1087162 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		PAR10_HUMAN (326-530): 1.28e-20: 98: 14.82