HitPredict

Interactor 1: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton GO:0046777 - protein autophosphorylation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 855 Hs			1 1746
+	Hs
		1083894 NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		508196 FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		385530 NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		608132 FGFR4_HUMAN (537-849): 4.35e-98: 325: 34.78		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		435763 IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		968486 ROR2_HUMAN (551-854): 8.47e-56: 209: 38.39		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		665432 EPHA3_HUMAN (554-845): 1.09e-54: 206: 38.93		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Rn
		88928 INSR_RAT (511-849): 4.34e-54: 206: 37.46		D4A563_RAT (1-1746): 0: 2074: 85.98
+	Hs
		851514 DDR2_HUMAN (1-855): 0: 857: 100.00		NEK4_HUMAN (1483-1657): 6.72e-12: 72.9: 21.91
+	Hs
		507876 FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		507838 FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		607895 FGFR4_HUMAN (537-849): 4.35e-98: 325: 34.78		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		412046 FYN_HUMAN (548-850): 3.85e-99: 320: 35.64		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		522810 SRC_HUMAN (521-850): 1.38e-97: 316: 31.52		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		411994 FYN_HUMAN (548-850): 3.85e-99: 320: 35.64		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		508055 FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49		OBSCN_HUMAN (933-1713): 2.16e-56: 220: 11.37
+	Hs
		435552 IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568630 ROR2_HUMAN (551-854): 8.47e-56: 209: 38.39		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		522780 SRC_HUMAN (521-850): 1.38e-97: 316: 31.52		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17