HitPredict

Interactor 1: PTPRN (Q16849)
Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
Gene: PTPRN

Interactor 2: PTPR2 (Q92932)
Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
Gene: PTPRN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Receptor_IA-2~Receptor_IA-2, Y_phosphatase~Y_phosphatase
Common GO terms GO:0005886 - plasma membrane
GO:0030141 - secretory granule
GO:0035773 - insulin secretion involved in cellular response to glucose stimulus
GO:0045202 - synapse
GO:0051046 - regulation of secretion
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 979
Hs

1 1015
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Last updated: 15 Jul 2024