HitPredict

Interactor 1: PK1 (Q17850)
Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1)
Gene: pak-1

Interactor 2: Q95PW9 (Q95PW9)
NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family
Gene: nck-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.595

Property	Details
Experiments	31462781, 23549480
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016310 - phosphorylation GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 572 Ce			1 395
+	Hs
		209044 PAK1_HUMAN (6-568): 2.02e-167: 488: 51.58		NCK2_HUMAN (2-393): 1.95e-85: 266: 37.31
+	Hs
		277595 PAK3_HUMAN (1-570): 1.08e-170: 497: 52.72		NCK1_HUMAN (2-394): 6.74e-80: 252: 37.78
+	Hs
		209045 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		NCK2_HUMAN (2-393): 1.95e-85: 266: 37.31
+	Hs
		557676 PAK1_HUMAN (6-568): 2.02e-167: 488: 51.58		NCK1_HUMAN (2-394): 6.74e-80: 252: 37.78
+	Mm
		292046 PAK1_MOUSE (5-568): 5.31e-166: 484: 51.49		NCK1_MOUSE (2-394): 4.78e-80: 252: 37.28
+	Hs
		557677 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		NCK1_HUMAN (2-394): 6.74e-80: 252: 37.78
+	Hs
		411702 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		LCK_HUMAN (176-378): 5.2e-55: 190: 30.05
+	Hs
		277606 PAK3_HUMAN (1-570): 1.08e-170: 497: 52.72		ITSN1_HUMAN (5-269): 1.04e-31: 129: 14.46
+	Hs
		924536 PAK1_HUMAN (6-568): 2.02e-167: 488: 51.58		GRB2_HUMAN (5-175): 1.72e-28: 112: 20.37
+	Hs
		924538 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		GRB2_HUMAN (5-175): 1.72e-28: 112: 20.37
+	Hs
		442822 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		HCK_HUMAN (2-186): 3.18e-19: 91.4: 16.13
+	Hs
		412169 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Hs
		433338 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		YES_HUMAN (5-108): 6.99e-17: 84.4: 17.93
+	Hs
		522955 PAK2_HUMAN (1-568): 3.78e-165: 481: 50.96		SRC_HUMAN (43-217): 1.14e-12: 71.3: 16.95
+	Mm
		593485 KPCA_MOUSE (100-566): 4.84e-132: 402: 18.62		GRB2_MOUSE (5-175): 1.35e-28: 113: 20.83
+	Mm
		643056 AKT1_MOUSE (223-572): 1.04e-128: 387: 21.05		P85A_MOUSE (270-393): 5.53e-20: 94.1: 19.69
+	Hs
		412163 STK4_HUMAN (272-572): 3.37e-128: 386: 39.93		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Hs
		412046 AKT1_HUMAN (223-572): 7.63e-126: 379: 21.61		FYN_HUMAN (6-244): 7.07e-19: 90.2: 12.45
+	Mm
		403418 AKT1_MOUSE (223-572): 1.04e-128: 387: 21.05		SRC_MOUSE (43-180): 9.38e-12: 68.3: 21.58
+	Hs
		522810 AKT1_HUMAN (223-572): 7.63e-126: 379: 21.61		SRC_HUMAN (43-217): 1.14e-12: 71.3: 16.95