HitPredict

Interactor 1: H0YKT8 (H0YKT8)
Proteasome subunit beta
Gene: PSMA4

Interactor 2: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 439
+	Hs
		92602 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		E9PMD8_HUMAN (8-294): 0: 508: 95.47
+	Hs
		92604 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		E9PMD8_HUMAN (8-294): 0: 508: 95.47
+	Hs
		572857 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00
+	Hs
		637667 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60
+	Dm
		771287 PSA2_DROME (1-178): 4.03e-76: 229: 37.08		PRS4_DROME (5-433): 2.8e-136: 400: 42.49
+	Hs
		572859 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00
+	Hs
		638104 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60
+	Dm
		771310 PSA2_DROME (1-178): 4.03e-76: 229: 37.08		Q9V405_DROME (6-438): 4.77e-130: 383: 37.64
+	Rn
		566253 PSA2_RAT (1-178): 1.13e-77: 233: 38.76		PRS8_RAT (65-437): 1.93e-126: 373: 44.39
+	Hs
		637668 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39
+	Dm
		771298 PSA2_DROME (1-178): 4.03e-76: 229: 37.08		Q7KMQ0_DROME (21-433): 4.42e-126: 374: 36.87
+	Dm
		771309 PSA2_DROME (1-178): 4.03e-76: 229: 37.08		Q9V3V6_DROME (23-439): 7.96e-124: 367: 85.37
+	Hs
		637642 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59
+	Hs
		638105 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39
+	Dm
		186105 PSA2_DROME (1-178): 4.03e-76: 229: 37.08		PRS8_DROME (47-438): 5.38e-119: 354: 41.48
+	Hs
		108931 H0YKT8_HUMAN (1-181): 8.06e-71: 213: 100.00		PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59
+	Hs
		638078 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59
+	At
		286458 PSA4A_ARATH (1-179): 1.87e-73: 223: 61.45		PRS4A_ARATH (54-432): 1.1e-106: 324: 45.38
+	Hs
		637659 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17
+	Hs
		638098 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		TERA_HUMAN (162-434): 9.21e-77: 256: 35.17