HitPredict

Interactor 1: NHR28 (Q17905)
Nuclear hormone receptor family member nhr-28
Gene: nhr-28

Interactor 2: Q966B8 (Q966B8)
NR LBD domain-containing protein
Gene: nhr-237

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 437 Ce			1 345
+	Ce
		185050 NHR28_CAEEL (1-437): 8.12e-140: 409: 100.00		NHR53_CAEEL (2-342): 4.81e-75: 237: 25.78
+	Ce
		284137 NHR28_CAEEL (1-437): 8.12e-140: 409: 100.00		NHR42_CAEEL (1-339): 8.64e-72: 228: 38.38
+	Hs
		587112 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		RXRA_HUMAN (9-343): 3.62e-96: 294: 16.62
+	Hs
		782496 HNF4A_HUMAN (7-435): 1.31e-107: 327: 21.35		HNF4A_HUMAN (9-339): 9.61e-91: 281: 19.76
+	Ce
		106928 G5EEL3_CAEEL (5-377): 3.85e-111: 334: 57.59		Q95Y07_CAEEL (7-338): 6.02e-83: 257: 25.71
+	Ce
		106918 G5EEL3_CAEEL (5-377): 3.85e-111: 334: 57.59		NHR53_CAEEL (2-342): 4.81e-75: 237: 25.78
+	Hs
		490049 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		NR2F6_HUMAN (2-344): 8.28e-78: 245: 14.63
+	Hs
		377162 HNF4A_HUMAN (7-435): 1.31e-107: 327: 21.35		GCR_HUMAN (5-339): 1.78e-71: 238: 13.69
+	Hs
		587117 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		NR4A1_HUMAN (5-343): 1.82e-74: 242: 14.49
+	Ce
		106920 G5EEL3_CAEEL (5-377): 3.85e-111: 334: 57.59		NHR42_CAEEL (1-339): 8.64e-72: 228: 38.38
+	Hs
		500354 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		RARB_HUMAN (8-344): 3.07e-75: 240: 16.76
+	Mm
		509288 RXRA_MOUSE (5-378): 5.36e-106: 323: 20.32		RARA_MOUSE (8-344): 2.02e-72: 233: 16.48
+	Hs
		487899 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		RARA_HUMAN (8-344): 2.79e-72: 233: 16.48
+	Hs
		368969 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		ESR1_HUMAN (1-341): 3.01e-70: 231: 13.37
+	Hs
		265855 HNF4A_HUMAN (7-435): 1.31e-107: 327: 21.35		NR1I2_HUMAN (8-89): 3.68e-12: 68.9: 37.81
+	Mm
		659673 RXRA_MOUSE (5-378): 5.36e-106: 323: 20.32		PPARG_MOUSE (10-108): 1.72e-11: 67: 35.35
+	Hs
		265850 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		NR1I2_HUMAN (8-89): 3.68e-12: 68.9: 37.81
+	Mm
		659690 RXRA_MOUSE (5-378): 5.36e-106: 323: 20.32		NR1H3_MOUSE (4-89): 2.3e-11: 66.6: 37.78
+	Hs
		587130 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		PPARG_HUMAN (10-108): 2.17e-11: 66.6: 35.35
+	Hs
		510003 RXRA_HUMAN (5-378): 4.27e-105: 321: 20.32		ERR1_HUMAN (6-97): 3.47e-11: 65.9: 35.71