HitPredict

Interactor 1: RHG44 (Q17R89)
Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)
Gene: ARHGAP44

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	28514442, 32203420, 33961781, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0030425 - dendrite GO:0032956 - regulation of actin cytoskeleton organization
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 818 Hs			1 639
+	Hs
		1148393 RHG17_HUMAN (1-816): 1.66e-117: 378: 44.34		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1089305 RHG44_HUMAN (1-818): 1.01e-156: 479: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1066027 RHG44_HUMAN (1-818): 1.01e-156: 479: 100.00		ARHG6_HUMAN (52-634): 3.49e-68: 239: 13.68
+	Hs
		1377711 3BP1_HUMAN (1-589): 2.97e-86: 290: 39.22		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1148382 RHG17_HUMAN (1-816): 1.66e-117: 378: 44.34		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1285232 3BP1_HUMAN (1-589): 2.97e-86: 290: 39.22		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1191674 SRGP1_HUMAN (12-751): 2.95e-75: 267: 15.13		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		924636 RHG17_HUMAN (1-816): 1.66e-117: 378: 44.34		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		209014 CHIO_HUMAN (30-429): 4.28e-88: 288: 17.93		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		208987 CHIN_HUMAN (30-429): 8.69e-84: 277: 16.94		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		1148372 RHG17_HUMAN (1-816): 1.66e-117: 378: 44.34		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		253374 SRGP1_HUMAN (12-751): 2.95e-75: 267: 15.13		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		200200 SRGP3_HUMAN (12-710): 4.72e-73: 261: 14.75		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		253290 SRGP2_HUMAN (12-782): 1.01e-71: 256: 15.15		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		200212 SRGP3_HUMAN (12-710): 4.72e-73: 261: 14.75		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		557642 CHIO_HUMAN (30-429): 4.28e-88: 288: 17.93		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		551038 CHIN_HUMAN (30-429): 8.69e-84: 277: 16.94		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		253384 SRGP2_HUMAN (12-782): 1.01e-71: 256: 15.15		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Hs
		1049716 SRGP1_HUMAN (12-751): 2.95e-75: 267: 15.13		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87