HitPredict

Interactor 1: H0YKT8 (H0YKT8)
Proteasome subunit beta
Gene: PSMA4

Interactor 2: PSME2 (Q9UL46)
Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)
Gene: PSME2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PA28_beta~Proteasome
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 181 Hs			1 239
+	Hs
		637753 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		637666 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		638215 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		637676 PSA2_HUMAN (1-178): 1.38e-77: 233: 38.76		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		156373 PSA7_HUMAN (2-179): 8.31e-68: 208: 32.96		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		656335 PSA5_HUMAN (1-179): 2.12e-66: 204: 31.52		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		638103 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Dm
		771307 PSA2_DROME (1-178): 4.03e-76: 229: 37.08		Q9V3P3_DROME (16-239): 1.47e-100: 293: 32.77
+	Hs
		156268 PSA7_HUMAN (2-179): 8.31e-68: 208: 32.96		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		656192 PSA5_HUMAN (1-179): 2.12e-66: 204: 31.52		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		108942 H0YKT8_HUMAN (1-181): 8.06e-71: 213: 100.00		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		638116 PSA4_HUMAN (1-181): 1.2e-69: 213: 100.00		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		156276 PSA7_HUMAN (2-179): 8.31e-68: 208: 32.96		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		656208 PSA5_HUMAN (1-179): 2.12e-66: 204: 31.52		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Dm
		1278635 PSA5_DROME (1-179): 2.3e-67: 207: 27.96		Q9V3P3_DROME (16-239): 1.47e-100: 293: 32.77
+	Hs
		893656 PSA6_HUMAN (2-180): 6.87e-65: 201: 28.73		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Dm
		574030 PSA4_DROME (1-181): 9.01e-66: 203: 73.37		Q9V3P3_DROME (16-239): 1.47e-100: 293: 32.77
+	Dm
		611651 PSA71_DROME (2-181): 2.94e-64: 199: 28.18		Q9V3P3_DROME (16-239): 1.47e-100: 293: 32.77
+	Hs
		898972 PSMA8_HUMAN (2-173): 2.76e-30: 112: 35.75		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60