HitPredict

Interactor 1: RAP1 (Q18246)
Ras-related protein Rap-1 (EC 3.6.5.2)
Gene: rap-1

Interactor 2: Q19770 (Q19770)
Ras guanyl-releasing protein 3
Gene: rgef-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21482356
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, Ras~RasGEF
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 188 Ce			1 654
+	Hs
		919681 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RGL1_HUMAN (6-469): 1.84e-101: 328: 12.52
+	Hs
		897964 RAP1B_HUMAN (1-188): 5.27e-80: 237: 83.07		RGL1_HUMAN (6-469): 1.84e-101: 328: 12.52
+	Hs
		171541 RAP1B_HUMAN (1-188): 5.27e-80: 237: 83.07		RGL2_HUMAN (11-491): 1.56e-94: 310: 15.31
+	Hs
		919625 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RPGF1_HUMAN (8-399): 1.23e-82: 283: 17.49
+	Hs
		919656 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RPGF4_HUMAN (98-389): 1.46e-82: 282: 17.11
+	Dm
		442968 RAP1_DROME (1-165): 2.07e-82: 243: 89.70		Q9GR11_DROME (3-448): 3.7e-82: 277: 15.91
+	Dm
		442959 RAP1_DROME (1-165): 2.07e-82: 243: 89.70		Q86BI2_DROME (3-448): 4.5e-82: 276: 15.91
+	Dm
		442969 RAP1_DROME (1-165): 2.07e-82: 243: 89.70		Q9U4U5_DROME (3-448): 3.86e-78: 269: 15.91
+	Hs
		919657 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RPGF5_HUMAN (138-387): 6.93e-76: 255: 23.74
+	Hs
		897984 RAP2B_HUMAN (1-188): 1.58e-65: 200: 61.38		RPGF1_HUMAN (8-399): 1.23e-82: 283: 17.49
+	Dm
		442976 RAP1_DROME (1-165): 2.07e-82: 243: 89.70		Q9VMF3_DROME (144-353): 4.97e-65: 235: 22.07
+	Hs
		313171 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RPGF3_HUMAN (134-377): 6.91e-62: 223: 25.10
+	Hs
		486043 RAP2A_HUMAN (1-184): 2.87e-61: 189: 61.41		RPGF4_HUMAN (98-389): 1.46e-82: 282: 17.11
+	Hs
		313169 RAP1B_HUMAN (1-188): 5.27e-80: 237: 83.07		RPGF3_HUMAN (134-377): 6.91e-62: 223: 25.10
+	Hs
		313164 RAP2A_HUMAN (1-184): 2.87e-61: 189: 61.41		RPGF3_HUMAN (134-377): 6.91e-62: 223: 25.10
+	Hs
		919687 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RPGF2_HUMAN (11-151): 1.26e-10: 66.9: 12.68
+	Hs
		919653 RAP1A_HUMAN (1-169): 2.86e-84: 248: 89.41		RPGF6_HUMAN (11-146): 7.24e-10: 64.6: 16.06
+	Hs
		897996 RAP2B_HUMAN (1-188): 1.58e-65: 200: 61.38		RPGF2_HUMAN (11-151): 1.26e-10: 66.9: 12.68
+	Sc
		431335 RSR1_YEAST (1-171): 1.6e-65: 203: 59.88		LTE1_YEAST (193-342): 1.36e-09: 63.5: 29.14
+	Hs
		486041 RAP2A_HUMAN (1-184): 2.87e-61: 189: 61.41		RPGF6_HUMAN (11-146): 7.24e-10: 64.6: 16.06