HitPredict

Interactor 1: KPC3 (Q19266)
Protein kinase C-like 3 (EC 2.7.11.13) (Atypical protein kinase C-3) (aPKC3)
Gene: pkc-3

Interactor 2: NUMB1 (Q9XTY6)
Numb-related protein 1 (CKA1) (Protein kinase C adapter 1)
Gene: num-1

Species: Caenorhabditis elegans

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.605

Property	Details
Experiments	11134024, 11134025
Identification Methods	coimmunoprecipitation, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0019904 - protein domain specific binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 597 Ce			1 593
+	Hs
		833586 KPCZ_HUMAN (2-597): 0: 628: 55.28		NUMB_HUMAN (59-583): 3.44e-82: 272: 28.60
+	Dm
		54643 APKC_DROME (2-597): 0: 621: 55.11		NUMB_DROME (47-584): 3.11e-65: 225: 31.04
+	Hs
		666081 KPCD_HUMAN (98-593): 6.24e-172: 505: 36.40		SHC1_HUMAN (39-420): 4.95e-47: 175: 12.65
+	Hs
		957168 KPCD_HUMAN (98-593): 6.24e-172: 505: 36.40		DAB2_HUMAN (59-586): 7.48e-46: 174: 13.05
+	Hs
		957223 AKT3_HUMAN (194-587): 7.53e-151: 444: 34.75		DAB2_HUMAN (59-586): 7.48e-46: 174: 13.05
+	Hs
		833582 KPCE_HUMAN (29-260): 1e-28: 123: 19.20		NUMB_HUMAN (59-583): 3.44e-82: 272: 28.60
+	Hs
		408578 KPCB_HUMAN (102-178): 8.52e-17: 86.1: 27.27		NUMB_HUMAN (59-583): 3.44e-82: 272: 28.60
+	Hs
		566327 KPCA_HUMAN (103-185): 1.94e-09: 62.6: 26.51		NUMB_HUMAN (59-583): 3.44e-82: 272: 28.60
+	Mm
		934633 KPCB_MOUSE (102-178): 8.3e-17: 86.1: 27.27		ANS1B_MOUSE (60-269): 9.01e-50: 188: 19.91
+	Mm
		593489 KPCA_MOUSE (128-250): 2.31e-16: 84.6: 19.05		ANS1B_MOUSE (60-269): 9.01e-50: 188: 19.91
+	Hs
		408600 KPCB_HUMAN (102-178): 8.52e-17: 86.1: 27.27		DAB2_HUMAN (59-586): 7.48e-46: 174: 13.05
+	Hs
		397157 KPCG_HUMAN (113-184): 1.48e-11: 69.3: 40.28		DAB2_HUMAN (59-586): 7.48e-46: 174: 13.05