HitPredict

Interactor 1: SYMC (Q20970)
Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)
Gene: mars-1

Interactor 2: SYIC (Q21926)
Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)
Gene: iars-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21685384
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Anticodon_3~tRNA-synt_1, Anticodon_1~tRNA-synt_1g, tRNA-synt_1~tRNA-synt_1g
Common GO terms	GO:0000049 - tRNA binding GO:0005524 - ATP binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 917 Ce			1 1141
+	Hs
		782994 SYMC_HUMAN (4-665): 0: 613: 53.64		SYIC_HUMAN (4-1137): 0: 1146: 55.92
+	Ce
		1094031 SYMC_CAEEL (1-917): 0: 897: 100.00		SYV_CAEEL (5-964): 0: 782: 18.38
+	Ce
		1000140 SYMC_CAEEL (1-917): 0: 897: 100.00		SYLC_CAEEL (9-1080): 0: 698: 14.79
+	Dm
		55967 A1ZBE9_DROME (4-759): 0: 579: 41.91		Q8MSW0_DROME (6-1141): 0: 1002: 51.57
+	Hs
		783023 AIMP1_HUMAN (630-917): 8.81e-100: 315: 40.39		SYIC_HUMAN (4-1137): 0: 1146: 55.92
+	Hs
		880186 SYMC_HUMAN (4-665): 0: 613: 53.64		SYLC_HUMAN (1-1069): 0: 770: 14.48
+	Dm
		52473 A1Z7K8_DROME (612-917): 1.79e-100: 318: 43.04		Q8MSW0_DROME (6-1141): 0: 1002: 51.57
+	Zm
		35744 A0A1D6LQQ9_MAIZE (2-195): 1.45e-37: 154: 16.20		A0A1D6LQQ9_MAIZE (9-1120): 0: 1047: 47.43
+	Sc
		450322 ARC1_YEAST (736-895): 1.49e-57: 204: 47.53		SYIC_YEAST (11-1063): 0: 966: 50.89
+	Tk
		1126767 SYM_THEKO (35-738): 2.26e-171: 517: 28.78		SYL_THEKO (11-956): 0: 592: 21.07
+	Hs
		1019454 AIMP1_HUMAN (630-917): 8.81e-100: 315: 40.39		SYLC_HUMAN (1-1069): 0: 770: 14.48
+	Hs
		643924 SYVC_HUMAN (4-219): 1.07e-44: 177: 11.98		SYLC_HUMAN (1-1069): 0: 770: 14.48
+	Hs
		783127 SYIC_HUMAN (7-171): 2.04e-41: 167: 18.38		SYLC_HUMAN (1-1069): 0: 770: 14.48