HitPredict

Interactor 1: ORC5 (Q24169)
Origin recognition complex subunit 5
Gene: ORC5

Interactor 2: Q9VSM9 (Q9VSM9)
Cell division control protein
Gene: Cdc6

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	32848132, 29899147
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA_22~ORC5_C
Common GO terms	GO:0003688 - DNA replication origin binding GO:0005634 - nucleus GO:0006270 - DNA replication initiation GO:0016887 - ATP hydrolysis activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 460 Dm			1 662
+	Dm
		184164 ORC5_DROME (1-460): 3.7e-174: 498: 100.00		ORC1_DROME (12-650): 1.39e-114: 367: 20.64
+	Hs
		217275 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		CDC6_HUMAN (87-655): 7.11e-143: 429: 32.09
+	Hs
		217257 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC1_HUMAN (6-647): 6.11e-134: 416: 21.11
+	At
		1150968 ORC5_ARATH (6-457): 3.06e-110: 337: 22.14		ORC1B_ARATH (32-651): 8.96e-146: 445: 18.58
+	Dm
		1096605 ORC5_DROME (1-460): 3.7e-174: 498: 100.00		Q9W102_DROME (246-656): 1.09e-73: 246: 13.28
+	Hs
		217213 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC4_HUMAN (230-658): 1.3e-91: 292: 14.89
+	Dm
		184170 ORC1_DROME (5-251): 1.08e-55: 200: 15.89		Q9VSM9_DROME (1-662): 4.61e-176: 518: 100.00
+	Sc
		842056 ORC5_YEAST (10-458): 3.66e-115: 348: 21.93		ORC1_YEAST (22-653): 2.01e-107: 348: 16.88
+	Sp
		195259 ORC5_SCHPO (4-456): 1.66e-111: 338: 23.90		ORC1_SCHPO (154-653): 3.67e-108: 344: 21.93
+	Sp
		195258 ORC5_SCHPO (4-456): 1.66e-111: 338: 23.90		CDC18_SCHPO (97-650): 2.8e-101: 322: 25.00
+	Hs
		1306109 CDC6_HUMAN (4-246): 4.03e-65: 221: 17.60		CDC6_HUMAN (87-655): 7.11e-143: 429: 32.09
+	Hs
		1033398 CDC6_HUMAN (4-246): 4.03e-65: 221: 17.60		ORC1_HUMAN (6-647): 6.11e-134: 416: 21.11
+	Sc
		447803 ORC5_YEAST (10-458): 3.66e-115: 348: 21.93		CDC6_YEAST (184-620): 4.11e-80: 265: 22.06
+	Sp
		195262 ORC5_SCHPO (4-456): 1.66e-111: 338: 23.90		ORC4_SCHPO (20-607): 2.18e-76: 265: 12.72
+	At
		1150967 ORC5_ARATH (6-457): 3.06e-110: 337: 22.14		ORC4_ARATH (243-654): 4.62e-74: 246: 16.05
+	Hs
		217212 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC5_HUMAN (262-449): 1.08e-33: 135: 16.34
+	Sc
		842058 ORC5_YEAST (10-458): 3.66e-115: 348: 21.93		ORC4_YEAST (205-617): 3.58e-61: 214: 13.29
+	Dm
		184172 ORC1_DROME (5-251): 1.08e-55: 200: 15.89		Q9W102_DROME (246-656): 1.09e-73: 246: 13.28