HitPredict

Interactor 1: ORC5 (Q24169)
Origin recognition complex subunit 5
Gene: ORC5

Interactor 2: ORC6 (Q9Y1B2)
Origin recognition complex subunit 6
Gene: ORC6

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.922

Property	Details
Experiments	24137536, 27016737, 25762138, 29899147, 32848132
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	ORC5_C~ORC6
Common GO terms	GO:0005634 - nucleus GO:0005664 - nuclear origin of replication recognition complex GO:0006260 - DNA replication GO:0006270 - DNA replication initiation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 460 Dm			1 257
+	Hs
		217287 ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69		ORC6_HUMAN (2-241): 3.24e-98: 288: 27.82
+	At
		1150969 ORC5_ARATH (6-457): 3.06e-110: 337: 22.14		ORC6_ARATH (5-233): 3.57e-92: 275: 22.58
+	Dm
		184173 ORC1_DROME (5-251): 1.08e-55: 200: 15.89		ORC6_DROME (1-257): 5.75e-113: 326: 100.00
+	Dm
		1373671 Q9VSM9_DROME (4-223): 2.55e-52: 188: 15.04		ORC6_DROME (1-257): 5.75e-113: 326: 100.00
+	Hs
		1306132 CDC6_HUMAN (4-246): 4.03e-65: 221: 17.60		ORC6_HUMAN (2-241): 3.24e-98: 288: 27.82
+	At
		1352830 ORC1B_ARATH (4-223): 1.01e-53: 194: 15.88		ORC6_ARATH (5-233): 3.57e-92: 275: 22.58
+	Hs
		217846 ORC4_HUMAN (2-255): 3.7e-42: 156: 16.00		ORC6_HUMAN (2-241): 3.24e-98: 288: 27.82
+	Dm
		1376237 Q9W102_DROME (27-183): 2.47e-18: 89: 10.92		ORC6_DROME (1-257): 5.75e-113: 326: 100.00
+	At
		1150972 ORC4_ARATH (16-250): 2.46e-16: 82.5: 10.98		ORC6_ARATH (5-233): 3.57e-92: 275: 22.58