HitPredict

Interactor 1: Q24253 (Q24253)
AP complex subunit beta
Gene: AP-1-2beta

Interactor 2: Q9VDC3 (Q9VDC3)
AP complex subunit sigma
Gene: AP-2sigma

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport GO:0030122 - AP-2 adaptor complex GO:0035615 - clathrin adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 921 Dm			1 142
+	Hs
		903681 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP1S1_HUMAN (1-142): 1.95e-51: 162: 45.07
+	Hs
		880408 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		925978 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP1S3_HUMAN (1-142): 1.17e-49: 157: 43.66
+	Hs
		903682 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP1S1_HUMAN (1-142): 1.95e-51: 162: 45.07
+	Dm
		248295 Q24253_DROME (1-921): 0: 852: 100.00		O62530_DROME (1-138): 2.32e-42: 146: 16.67
+	Hs
		880409 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP1S2_HUMAN (2-142): 4.11e-51: 161: 46.81
+	Hs
		1014066 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP1S3_HUMAN (1-142): 1.17e-49: 157: 43.66
+	Hs
		925992 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP1M1_HUMAN (2-137): 3.51e-44: 151: 14.71
+	Hs
		926066 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP1M2_HUMAN (2-142): 2.73e-44: 151: 20.14
+	Hs
		864065 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78
+	Hs
		1014074 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP1M1_HUMAN (2-137): 3.51e-44: 151: 14.71
+	Hs
		1014107 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP1M2_HUMAN (2-142): 2.73e-44: 151: 20.14
+	Hs
		925969 AP2B1_HUMAN (1-920): 0: 843: 72.07		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Hs
		864070 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78
+	Hs
		1014061 AP1B1_HUMAN (1-920): 0: 837: 72.21		AP2M1_HUMAN (1-138): 1.51e-41: 144: 15.22
+	Ce
		725366 Q9N4F3_CAEEL (1-918): 0: 760: 66.70		AP2M_CAEEL (1-138): 1.9e-43: 149: 15.94
+	Ce
		725358 Q9N4F3_CAEEL (1-918): 0: 760: 66.70		AP1M_CAEEL (3-137): 9.07e-43: 147: 20.00
+	At
		1196570 APBLB_ARATH (3-920): 0: 762: 57.44		AP2S_ARATH (1-142): 1.23e-44: 144: 59.86
+	Zm
		30064 A0A1D6K3D9_MAIZE (41-919): 0: 726: 56.17		Q9MAY9_MAIZE (2-136): 3.48e-42: 139: 17.99
+	Hs
		321516 AP2A1_HUMAN (11-916): 0: 651: 16.24		AP2S1_HUMAN (1-142): 4.85e-46: 148: 95.78