HitPredict

Interactor 1: CUL1 (Q24311)
Cullin homolog 1 (Lin-19 homolog protein)
Gene: CUL1

Interactor 2: CAND1 (Q9VKY2)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1)
Gene: CAND1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	20691177
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~TIP120
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 774 Dm			1 1248
+	Mm
		1169688 CUL1_MOUSE (2-774): 0: 828: 61.72		CAND1_MOUSE (3-1248): 0: 828: 57.70
+	Hs
		1041074 CUL1_HUMAN (3-774): 0: 825: 61.68		CAND1_HUMAN (3-1248): 0: 830: 57.78
+	Mm
		1169706 CUL1_MOUSE (2-774): 0: 828: 61.72		CAND2_MOUSE (3-1240): 0: 788: 50.80
+	Hs
		1043084 CUL4A_HUMAN (17-774): 0: 774: 29.84		CAND1_HUMAN (3-1248): 0: 830: 57.78
+	Hs
		1041947 CUL3_HUMAN (3-774): 0: 771: 27.45		CAND1_HUMAN (3-1248): 0: 830: 57.78
+	Hs
		1043440 CUL4B_HUMAN (3-774): 0: 756: 29.18		CAND1_HUMAN (3-1248): 0: 830: 57.78
+	Hs
		256748 CUL1_HUMAN (3-774): 0: 825: 61.68		CAND2_HUMAN (3-1240): 0: 761: 51.64
+	Dm
		1213848 Q8IP45_DROME (3-774): 0: 749: 27.50		CAND1_DROME (1-1248): 0: 803: 100.00
+	Hs
		256749 CUL3_HUMAN (3-774): 0: 771: 27.45		CAND2_HUMAN (3-1240): 0: 761: 51.64
+	Ce
		105745 CUL1_CAEEL (6-774): 0: 760: 41.92		CAND1_CAEEL (4-1248): 0: 578: 34.79
+	Sp
		142920 CUL1_SCHPO (11-774): 0: 754: 39.66		CAND1_SCHPO (12-1237): 4.64e-112: 382: 18.45
+	Hs
		1042184 CUL3_HUMAN (3-774): 0: 771: 27.45		GCN1_HUMAN (7-1245): 1.89e-68: 256: 12.40
+	Hs
		127264 CUL3_HUMAN (3-774): 0: 771: 27.45		IPO5_HUMAN (306-1244): 4.89e-27: 121: 10.48
+	Hs
		268708 CUL1_HUMAN (3-774): 0: 825: 61.68		SF3B1_HUMAN (727-1245): 6.28e-09: 62.7: 10.59
+	Hs
		1042209 CUL3_HUMAN (3-774): 0: 771: 27.45		TNPO1_HUMAN (633-1244): 4.31e-22: 105: 13.38
+	Hs
		1043050 CUL4A_HUMAN (17-774): 0: 774: 29.84		ECM29_HUMAN (206-1191): 1.47e-19: 97.8: 11.77
+	Hs
		1041774 CUL3_HUMAN (3-774): 0: 771: 27.45		ECM29_HUMAN (206-1191): 1.47e-19: 97.8: 11.77
+	Hs
		787480 CUL4A_HUMAN (17-774): 0: 774: 29.84		MTOR_HUMAN (1-617): 4.56e-13: 76.4: 11.86
+	Hs
		155572 CUL3_HUMAN (3-774): 0: 771: 27.45		TNPO2_HUMAN (622-1087): 9.2e-13: 75: 14.06
+	Hs
		268709 CUL3_HUMAN (3-774): 0: 771: 27.45		SF3B1_HUMAN (727-1245): 6.28e-09: 62.7: 10.59