HitPredict

Interactor 1: ESC (Q24338)
Polycomb protein esc (Protein extra sex combs)
Gene: ESC

Interactor 2: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	11124122, 11581156, 12697833, 15896722, 12533794
Identification Methods	affinity chromatography technology, pull down, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005700 - polytene chromosome GO:0031507 - heterochromatin formation and 1 others more... GO:0035098 - ESC/E(Z) complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Dm			1 521
+	Hs
		245623 TBL1X_HUMAN (1-315): 6.08e-60: 206: 11.59		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1270423 TBL1R_HUMAN (122-425): 4.33e-59: 202: 15.50		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		245600 TBL1X_HUMAN (1-315): 6.08e-60: 206: 11.59		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1038686 TBL1R_HUMAN (122-425): 4.33e-59: 202: 15.50		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1270358 FBXW7_HUMAN (1-239): 7.98e-39: 150: 11.07		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		209431 PLRG1_HUMAN (41-326): 2.21e-38: 146: 16.94		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		177148 TBL1X_HUMAN (1-315): 6.08e-60: 206: 11.59		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Hs
		177377 TBL1R_HUMAN (122-425): 4.33e-59: 202: 15.50		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Hs
		903404 WDR5_HUMAN (255-425): 4.13e-28: 115: 10.98		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1270370 SNR40_HUMAN (1-154): 1.49e-27: 114: 11.32		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Dm
		1182201 EBI_DROME (119-425): 1.48e-60: 210: 13.95		Q7KTS4_DROME (5-428): 0: 556: 56.48
+	Dm
		1279322 EBI_DROME (119-425): 1.48e-60: 210: 13.95		Q9VNC2_DROME (5-428): 0: 553: 56.25
+	Hs
		903202 WDR5_HUMAN (255-425): 4.13e-28: 115: 10.98		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		863507 COPA_HUMAN (279-425): 2.59e-13: 74: 15.44		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		177249 WDR5_HUMAN (255-425): 4.13e-28: 115: 10.98		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Hs
		177369 TBL1Y_HUMAN (1-106): 1.39e-17: 86.8: 12.26		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Sp
		140687 COPA_SCHPO (54-309): 1.32e-30: 126: 13.27		PHD1_SCHPO (5-406): 0: 519: 52.84
+	Hs
		245584 TBL1X_HUMAN (1-315): 6.08e-60: 206: 11.59		HDAC4_HUMAN (5-405): 2.08e-133: 415: 22.86
+	Hs
		880817 TBL1R_HUMAN (122-425): 4.33e-59: 202: 15.50		HDAC4_HUMAN (5-405): 2.08e-133: 415: 22.86
+	Mm
		1157751 COPA_MOUSE (83-330): 2.64e-21: 98.7: 14.14		HDAC4_MOUSE (5-405): 1.49e-134: 418: 23.83