HitPredict

Interactor 1: STX1A (Q24547)
Syntaxin-1A (dSynt1)
Gene: Syx1A

Interactor 2: Q7JYX5 (Q7JYX5)
Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1)
Gene: Vamp7

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.850

Property	Details
Experiments	15710747, 28403141, 22036573
Identification Methods	two hybrid, affinity chromatography technology, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005765 - lysosomal membrane GO:0006887 - exocytosis GO:0006906 - vesicle fusion and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 291 Dm			1 218
+	Rn
		699183 STX1A_RAT (3-290): 2.59e-76: 236: 68.40		VAMP7_RAT (1-218): 6.34e-85: 252: 51.84
+	Hs
		850569 STX1A_HUMAN (3-290): 2.04e-75: 233: 68.40		VAMP7_HUMAN (1-218): 2.8e-84: 250: 52.29
+	Hs
		850561 STX4_HUMAN (3-287): 3.62e-58: 189: 40.41		VAMP7_HUMAN (1-218): 2.8e-84: 250: 52.29
+	Hs
		850562 STX3_HUMAN (3-267): 2.31e-57: 187: 58.87		VAMP7_HUMAN (1-218): 2.8e-84: 250: 52.29
+	Mm
		139056 STX1A_MOUSE (3-290): 3.18e-76: 235: 68.75		SC22B_MOUSE (23-206): 2.46e-64: 200: 20.54
+	Hs
		263248 STX1A_HUMAN (3-290): 2.04e-75: 233: 68.40		SC22B_HUMAN (23-206): 2.46e-64: 200: 20.54
+	Hs
		263179 STX2_HUMAN (3-287): 1.3e-73: 229: 60.35		SC22B_HUMAN (23-206): 2.46e-64: 200: 20.54
+	Dm
		115805 STX1A_DROME (1-291): 4.25e-78: 240: 100.00		M9PGI6_DROME (24-206): 1.15e-56: 180: 25.54
+	Dm
		1098114 STX1A_DROME (1-291): 4.25e-78: 240: 100.00		Q9W3M8_DROME (5-179): 3.75e-50: 163: 22.16
+	Hs
		263226 STX4_HUMAN (3-287): 3.62e-58: 189: 40.41		SC22B_HUMAN (23-206): 2.46e-64: 200: 20.54
+	Dm
		577220 STX1A_DROME (1-291): 4.25e-78: 240: 100.00		SYB_DROME (97-208): 5.85e-35: 123: 16.07
+	Hs
		180867 STX3_HUMAN (3-267): 2.31e-57: 187: 58.87		YKT6_HUMAN (22-179): 6.23e-54: 173: 27.67
+	Hs
		261664 STX1A_HUMAN (3-290): 2.04e-75: 233: 68.40		VAMP4_HUMAN (124-193): 1.01e-13: 67.4: 40.00
+	Hs
		1083981 STX1A_HUMAN (3-290): 2.04e-75: 233: 68.40		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71
+	Rn
		699186 STX1A_RAT (3-290): 2.59e-76: 236: 68.40		VAMP8_RAT (124-189): 3.94e-10: 57: 34.85
+	Hs
		699284 STX2_HUMAN (3-287): 1.3e-73: 229: 60.35		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71
+	Hs
		261655 STX4_HUMAN (3-287): 3.62e-58: 189: 40.41		VAMP4_HUMAN (124-193): 1.01e-13: 67.4: 40.00
+	Hs
		261658 STX3_HUMAN (3-267): 2.31e-57: 187: 58.87		VAMP4_HUMAN (124-193): 1.01e-13: 67.4: 40.00
+	Hs
		1017775 STX4_HUMAN (3-287): 3.62e-58: 189: 40.41		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71
+	Hs
		1030183 STX3_HUMAN (3-267): 2.31e-57: 187: 58.87		VAMP8_HUMAN (124-193): 2.6e-11: 60.1: 35.71