HitPredict

Interactor 1: JAK (Q24592)
Tyrosine-protein kinase hopscotch (EC 2.7.10.2)
Gene: hop

Interactor 2: Q8INY1 (Q8INY1)
Suppressor of cytokine signaling at 36E, isoform D
Gene: Socs36E

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	23885117, 27194748
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005126 - cytokine receptor binding GO:0007298 - border follicle cell migration GO:0007616 - long-term memory GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1177 Dm			1 737
+	Dm
		1099225 JAK_DROME (1-1177): 0: 920: 100.00		Q7JVF1_DROME (415-614): 2.94e-43: 161: 20.91
+	Hs
		433231 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		SRC_HUMAN (307-646): 2.77e-46: 175: 14.55
+	Hs
		146582 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		SOCS2_HUMAN (431-613): 6.69e-49: 172: 28.28
+	Hs
		522734 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		SRC_HUMAN (307-646): 2.77e-46: 175: 14.55
+	Gg
		337663 SRC_CHICK (854-1166): 2.89e-105: 343: 28.48		SRC_CHICK (341-646): 2.11e-45: 172: 13.93
+	Hs
		411946 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		FYN_HUMAN (351-601): 1.01e-43: 167: 15.59
+	Hs
		146668 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		SOCS7_HUMAN (285-612): 2.11e-42: 164: 21.17
+	Hs
		411969 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		FYN_HUMAN (351-601): 1.01e-43: 167: 15.59
+	Hs
		411552 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		LCK_HUMAN (384-628): 1.8e-42: 163: 13.89
+	Hs
		147377 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		SOCS3_HUMAN (435-610): 7.01e-45: 162: 24.20
+	Hs
		442772 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		HCK_HUMAN (304-622): 5.98e-43: 165: 15.92
+	Hs
		411573 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		LCK_HUMAN (384-628): 1.8e-42: 163: 13.89
+	Hs
		433263 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		P85A_HUMAN (468-640): 4.84e-40: 159: 21.47
+	Hs
		522796 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		P85A_HUMAN (468-640): 4.84e-40: 159: 21.47
+	Hs
		522848 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		CRK_HUMAN (462-640): 2.53e-41: 155: 20.90
+	Hs
		181770 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		SOCS1_HUMAN (450-613): 9.39e-41: 150: 25.61
+	Hs
		181783 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		SOCS1_HUMAN (450-613): 9.39e-41: 150: 25.61
+	Hs
		522758 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		PLCG1_HUMAN (458-619): 6.1e-23: 106: 18.94
+	Hs
		129185 SRC_HUMAN (854-1166): 3.12e-105: 343: 28.48		P85B_HUMAN (464-570): 5.41e-22: 103: 24.55
+	Hs
		433433 YES_HUMAN (731-1166): 5.28e-106: 346: 22.90		P55G_HUMAN (470-582): 6.9e-19: 92.2: 21.55