HitPredict

Interactor 1: MCM4 (Q26454)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Protein disc proliferation abnormal)
Gene: dpa

Interactor 2: MCM6 (Q9V461)
DNA replication licensing factor Mcm6 (DmMCM6) (EC 3.6.4.12)
Gene: MCM6

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.896

The method score is based on:

Property Details
Experiments 25117490, 22036573, 16798881, 11726693
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM6_C, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM6_C~MCM_lid, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006260 - DNA replication
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 866
Dm

1 817
+ Xl
+ Hs
+ Dm
+ Dm
+ Dm
+ Xl
+ Hs
+ Hs
+ At
+ Hs
+ Xl
+ Hs
+ Xl
+ Hs
+ Ce
+ Sc
+ Sc
+ Sp
+ Sc
+ Sc

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Last updated: 15 Jul 2024