HitPredict

Interactor 1: H2KZU3 (H2KZU3)
NR LBD domain-containing protein
Gene: nhr-21

Interactor 2: Q7KX66 (Q7KX66)
Nuclear receptor domain-containing protein
Gene: nhr-88

Species: Caenorhabditis elegans

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 446 Ce			1 235
+	Ce
		109776 H2KZU4_CAEEL (1-446): 3.75e-110: 334: 98.22		H2KZA1_CAEEL (1-206): 7.57e-74: 236: 100.00
+	Ce
		106935 NH114_CAEEL (12-442): 7.97e-96: 296: 20.42		H2KZA1_CAEEL (1-206): 7.57e-74: 236: 100.00
+	Hs
		369177 NR2C2_HUMAN (5-439): 7.37e-101: 314: 15.15		ESR1_HUMAN (11-228): 1.49e-66: 217: 27.27
+	Hs
		782501 NR2C2_HUMAN (5-439): 7.37e-101: 314: 15.15		HNF4A_HUMAN (14-235): 3.14e-67: 216: 29.60
+	Hs
		622775 NR2C2_HUMAN (5-439): 7.37e-101: 314: 15.15		COT2_HUMAN (5-218): 3.9e-66: 211: 28.89
+	Ce
		109952 H2KZU3_CAEEL (1-446): 2e-113: 342: 100.00		NHR31_CAEEL (28-189): 5.54e-53: 181: 45.61
+	Ce
		109946 H2KZU3_CAEEL (1-446): 2e-113: 342: 100.00		NHR4_CAEEL (2-199): 1.04e-50: 173: 27.54
+	Ce
		109976 H2KZU4_CAEEL (1-446): 3.75e-110: 334: 98.22		NHR31_CAEEL (28-189): 5.54e-53: 181: 45.61
+	Hs
		659697 NR2C2_HUMAN (5-439): 7.37e-101: 314: 15.15		RXRB_HUMAN (31-230): 9.6e-61: 200: 30.50
+	Ce
		109969 H2KZU4_CAEEL (1-446): 3.75e-110: 334: 98.22		NHR4_CAEEL (2-199): 1.04e-50: 173: 27.54
+	Ce
		109959 H2KZU3_CAEEL (1-446): 2e-113: 342: 100.00		Q86PI8_CAEEL (33-141): 3.09e-29: 112: 46.85
+	Ce
		106937 H2KZU4_CAEEL (1-446): 3.75e-110: 334: 98.22		NH114_CAEEL (33-141): 2.48e-29: 115: 46.85
+	Ce
		137568 NHR4_CAEEL (7-445): 7.66e-102: 314: 27.27		NHR62_CAEEL (36-175): 2.56e-28: 113: 37.86
+	Ce
		220027 NHR4_CAEEL (7-445): 7.66e-102: 314: 27.27		NHR61_CAEEL (35-134): 1.04e-28: 113: 48.25
+	Hs
		823684 NR2C2_HUMAN (5-439): 7.37e-101: 314: 15.15		NR2C2_HUMAN (36-140): 1.87e-25: 105: 40.95
+	Ce
		106933 NH114_CAEEL (12-442): 7.97e-96: 296: 20.42		NH114_CAEEL (33-141): 2.48e-29: 115: 46.85