HitPredict

Interactor 1: H2KZU4 (H2KZU4)
NR LBD domain-containing protein
Gene: nhr-21

Interactor 2: FOXO (O16850)
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)
Gene: daf-16

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Ce			1 541
+	Ce
		109944 H2KZU3_CAEEL (1-450): 2.08e-118: 355: 98.89		FOXO_CAEEL (1-541): 0: 751: 100.00
+	Ce
		106942 NH114_CAEEL (12-443): 6.28e-95: 294: 20.37		FOXO_CAEEL (1-541): 0: 751: 100.00
+	Hs
		369258 ESR1_HUMAN (4-447): 3.13e-85: 274: 17.56		FOXA1_HUMAN (103-399): 1.04e-60: 209: 18.77
+	Ce
		106959 NH114_CAEEL (12-443): 6.28e-95: 294: 20.37		PHA4_CAEEL (129-372): 2.2e-47: 174: 18.07
+	Hs
		206786 ESR1_HUMAN (4-447): 3.13e-85: 274: 17.56		FOXO3_HUMAN (121-369): 1.73e-51: 188: 42.17
+	Hs
		206818 NR1H2_HUMAN (16-446): 5.58e-85: 269: 17.32		FOXO3_HUMAN (121-369): 1.73e-51: 188: 42.17
+	Ce
		109784 H2KZA1_CAEEL (20-448): 4.26e-88: 281: 22.35		PHA4_CAEEL (129-372): 2.2e-47: 174: 18.07
+	Hs
		369425 ESR1_HUMAN (4-447): 3.13e-85: 274: 17.56		FOXK2_HUMAN (122-391): 5.63e-49: 181: 21.46
+	Ce
		109782 H2KZA1_CAEEL (20-448): 4.26e-88: 281: 22.35		FKH6_CAEEL (168-389): 1.5e-48: 172: 24.89
+	Hs
		823946 NR2C2_HUMAN (22-448): 2.52e-93: 295: 15.50		FOXL1_HUMAN (152-332): 4.23e-43: 158: 22.04
+	Hs
		369487 ESR1_HUMAN (4-447): 3.13e-85: 274: 17.56		FOXO1_HUMAN (117-442): 8.5e-48: 178: 33.23
+	Ce
		220329 NHR49_CAEEL (13-441): 9.23e-87: 275: 20.19		PHA4_CAEEL (129-372): 2.2e-47: 174: 18.07
+	Hs
		206833 NR1H3_HUMAN (13-446): 1.67e-81: 260: 16.82		FOXO3_HUMAN (121-369): 1.73e-51: 188: 42.17
+	Hs
		369407 ESR1_HUMAN (4-447): 3.13e-85: 274: 17.56		FOXO4_HUMAN (142-385): 1.1e-46: 172: 37.90
+	Hs
		370724 ESR1_HUMAN (4-447): 3.13e-85: 274: 17.56		FOXJ3_HUMAN (134-377): 2.47e-45: 170: 26.02
+	Ce
		1088810 NHR31_CAEEL (2-443): 1.13e-78: 256: 21.25		PHA4_CAEEL (129-372): 2.2e-47: 174: 18.07
+	Ce
		1014601 NHR31_CAEEL (2-443): 1.13e-78: 256: 21.25		FKH6_CAEEL (168-389): 1.5e-48: 172: 24.89
+	Mm
		291643 ESR1_MOUSE (4-447): 1.22e-82: 267: 17.11		FOXL2_MOUSE (133-259): 9.29e-42: 155: 28.24
+	Mm
		291652 NR2C1_MOUSE (7-448): 5.26e-77: 252: 14.96		FOXL2_MOUSE (133-259): 9.29e-42: 155: 28.24
+	Hs
		525302 NR2C1_HUMAN (7-448): 1.05e-76: 252: 14.93		FOXL2_HUMAN (132-259): 3.21e-40: 151: 26.92