HitPredict

Interactor 1: Q29QQ9 (Q29QQ9)
Ribosomal RNA-processing protein 42
Gene: Rrp42

Interactor 2: Q9VC93 (Q9VC93)
Dis3, isoform A (EC 3.1.13.-) (Dis3, isoform B)
Gene: Dis3

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	19220816, 20421210, 22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, RNB~RNase_PH, OB_Dis3~RNase_PH_C
Common GO terms	GO:0000176 - nuclear exosome (RNase complex) GO:0000177 - cytoplasmic exosome (RNase complex) GO:0000178 - exosome (RNase complex) GO:0005652 - nuclear lamina
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 296 Dm			1 982
+	Dm
		1250326 Q8T4A9_DROME (3-286): 2.88e-75: 237: 20.98		Q9VC93_DROME (1-972): 0: 1284: 100.00
+	Dm
		1362696 Q9VK19_DROME (19-280): 9.09e-50: 166: 17.80		Q9VC93_DROME (1-972): 0: 1284: 100.00
+	Hs
		1284999 EXOS8_HUMAN (1-283): 8.6e-87: 262: 25.35		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Hs
		1063785 EXOS7_HUMAN (1-295): 1.18e-85: 260: 48.14		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Hs
		986739 EXOS9_HUMAN (1-286): 6.52e-71: 227: 25.35		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Hs
		1342631 EXOS4_HUMAN (14-285): 1.13e-53: 176: 17.03		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Sp
		252320 RRP45_SCHPO (2-287): 3.84e-75: 233: 21.88		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Hs
		1257149 EXOS8_HUMAN (1-283): 8.6e-87: 262: 25.35		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Hs
		1063744 EXOS7_HUMAN (1-295): 1.18e-85: 260: 48.14		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Sp
		740351 RRP43_SCHPO (3-265): 8.03e-68: 213: 25.10		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Sc
		984317 RRP45_YEAST (2-288): 1.08e-71: 225: 19.87		RRP44_YEAST (2-946): 0: 992: 41.26
+	At
		96521 RRP41_ARATH (20-288): 2.03e-55: 181: 16.54		F4INI6_ARATH (1-945): 0: 1030: 41.70
+	Hs
		986702 EXOS9_HUMAN (1-286): 6.52e-71: 227: 25.35		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Sp
		194782 RRP41_SCHPO (12-282): 5.14e-48: 162: 17.52		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Sp
		223963 RRP42_SCHPO (4-287): 2.66e-41: 146: 25.16		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Hs
		1257153 EXOS4_HUMAN (14-285): 1.13e-53: 176: 17.03		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Sc
		993688 RRP42_YEAST (4-231): 2.33e-42: 148: 23.28		RRP44_YEAST (2-946): 0: 992: 41.26
+	Sc
		809596 RRP41_YEAST (20-284): 9.96e-24: 98.7: 16.67		RRP44_YEAST (2-946): 0: 992: 41.26
+	Pf
		1212338 Q8ID62_PLAF7 (4-292): 5.63e-70: 225: 19.24		Q8IDB6_PLAF7 (4-936): 0: 807: 27.45