HitPredict

Interactor 1: DOK6 (Q2MHE5)
Docking protein 6 (Downstream of tyrosine kinase 6)
Gene: DOK6

Interactor 2: NTRK3 (Q6VNS1)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	20565848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 331 Mm			1 825
+	Hs
		1081513 DOK6_HUMAN (1-331): 5.98e-138: 396: 99.70		NTRK3_HUMAN (1-825): 0: 659: 95.59
+	Hs
		385782 IRS2_HUMAN (8-321): 9.56e-68: 232: 18.64		NTRK1_HUMAN (16-825): 7.84e-176: 528: 49.02
+	Hs
		434219 DOK6_HUMAN (1-331): 5.98e-138: 396: 99.70		RET_HUMAN (282-823): 5.27e-109: 361: 26.47
+	Hs
		434248 DOK4_HUMAN (1-316): 7.87e-122: 354: 63.50		RET_HUMAN (282-823): 5.27e-109: 361: 26.47
+	Hs
		151711 IRS4_HUMAN (6-269): 5.75e-65: 224: 19.33		FGFR4_HUMAN (164-823): 4.41e-161: 490: 24.75
+	Hs
		434299 DOK5_HUMAN (1-307): 1.22e-117: 343: 70.13		RET_HUMAN (282-823): 5.27e-109: 361: 26.47
+	Hs
		434273 DOK1_HUMAN (6-313): 1.36e-81: 257: 20.36		RET_HUMAN (282-823): 5.27e-109: 361: 26.47
+	Hs
		235038 DOK2_HUMAN (6-329): 2.94e-81: 254: 21.35		RET_HUMAN (282-823): 5.27e-109: 361: 26.47
+	Mm
		546269 DOK1_MOUSE (6-313): 5.84e-90: 279: 20.36		INSR_MOUSE (513-810): 6.98e-66: 241: 40.59
+	Hs
		724539 IRS1_HUMAN (2-329): 4.83e-80: 266: 18.85		DDR1_HUMAN (535-810): 3.04e-71: 253: 45.67
+	Mm
		724601 IRS1_MOUSE (5-329): 6.11e-83: 274: 19.83		IGF1R_MOUSE (513-806): 4.07e-67: 245: 40.13
+	Rn
		544792 IRS1_RAT (5-329): 1.85e-83: 276: 19.83		INSR_RAT (513-810): 1.1e-65: 241: 40.59
+	Mm
		546265 IRS1_MOUSE (5-329): 6.11e-83: 274: 19.83		INSR_MOUSE (513-810): 6.98e-66: 241: 40.59
+	Hs
		411322 IRS1_HUMAN (2-329): 4.83e-80: 266: 18.85		INSR_HUMAN (513-810): 5.24e-68: 248: 41.25
+	Hs
		435561 IRS1_HUMAN (2-329): 4.83e-80: 266: 18.85		IGF1R_HUMAN (513-806): 1.03e-67: 247: 41.02
+	Hs
		411486 DOK1_HUMAN (6-313): 1.36e-81: 257: 20.36		INSR_HUMAN (513-810): 5.24e-68: 248: 41.25
+	Hs
		724573 IRS1_HUMAN (2-329): 4.83e-80: 266: 18.85		ALK_HUMAN (513-802): 7.45e-63: 232: 40.88
+	Hs
		411534 IRS2_HUMAN (8-321): 9.56e-68: 232: 18.64		INSR_HUMAN (513-810): 5.24e-68: 248: 41.25
+	Hs
		435810 IRS2_HUMAN (8-321): 9.56e-68: 232: 18.64		IGF1R_HUMAN (513-806): 1.03e-67: 247: 41.02
+	Mm
		546280 DOK3_MOUSE (9-309): 1.14e-73: 235: 19.76		INSR_MOUSE (513-810): 6.98e-66: 241: 40.59