HitPredict

Interactor 1: RSPO1 (Q2MKA7)
R-spondin-1 (Roof plate-specific spondin-1) (hRspo1)
Gene: RSPO1

Interactor 2: LGR4 (Q9BXB1)
Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)
Gene: LGR4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

Property	Details
Experiments	25504990, 29752411, 24050775, 24165923, 24225776
Identification Methods	pull down, fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Furin-like_2~LRR_8
Common GO terms	GO:0016055 - Wnt signaling pathway GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 951
+	Hs
		1315144 RSPO3_HUMAN (8-251): 5.21e-65: 205: 46.31		LGR4_HUMAN (22-951): 0: 718: 100.00
+	Hs
		1166815 RSPO2_HUMAN (1-211): 8.67e-63: 198: 44.08		LGR4_HUMAN (22-951): 0: 718: 100.00
+	Hs
		1100838 RSPO4_HUMAN (1-208): 3.26e-46: 156: 38.94		LGR4_HUMAN (22-951): 0: 718: 100.00
+	Hs
		265892 RSPO1_HUMAN (1-263): 4.15e-81: 246: 100.00		LGR5_HUMAN (1-279): 1.21e-37: 154: 27.47
+	Hs
		265893 RSPO2_HUMAN (1-211): 8.67e-63: 198: 44.08		LGR5_HUMAN (1-279): 1.21e-37: 154: 27.47
+	Hs
		411273 INSR_HUMAN (15-174): 1.83e-35: 136: 15.91		PGS2_HUMAN (27-292): 7.13e-29: 121: 32.71
+	Hs
		1191117 FRAS1_HUMAN (14-207): 1.63e-17: 84.2: 17.14		PODN_HUMAN (35-262): 1.88e-30: 130: 28.94
+	Hs
		456805 FURIN_HUMAN (95-169): 4.79e-18: 85.3: 23.26		LSHR_HUMAN (29-227): 2.09e-13: 76.5: 23.08
+	Hs
		560488 PCSK6_HUMAN (14-155): 5.21e-09: 58.4: 15.82		TSHR_HUMAN (31-302): 4.28e-16: 85: 20.89