HitPredict

Interactor 1: RGPA2 (Q2PPJ7)
Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220)
Gene: RALGAPA2

Interactor 2: KBRS2 (Q9NYR9)
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)
Gene: NKIRAS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Rap_GAP~Ras
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1873 Hs			1 191
+	Hs
		349358 RGPA2_HUMAN (1-1873): 0: 2869: 100.00		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		914099 RGPA2_HUMAN (1-1873): 0: 2869: 100.00		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		1151781 RGPA1_HUMAN (1-851): 0: 1225: 48.66		KBRS2_HUMAN (1-191): 4.08e-85: 250: 100.00
+	Hs
		349400 RGPA1_HUMAN (1-851): 0: 1225: 48.66		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		895128 RGPA1_HUMAN (1-851): 0: 1225: 48.66		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		914140 RGPA1_HUMAN (1-851): 0: 1225: 48.66		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		1203746 RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54		KBRS2_HUMAN (1-191): 4.08e-85: 250: 100.00
+	Hs
		914181 RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		835037 TSC2_HUMAN (1477-1868): 4.37e-100: 360: 23.42		RAP1A_HUMAN (3-171): 6.1e-80: 237: 26.47
+	Hs
		506370 TSC2_HUMAN (1477-1868): 4.37e-100: 360: 23.42		RALA_HUMAN (6-176): 1.39e-76: 229: 26.32
+	Hs
		812872 RPGP1_HUMAN (1554-1848): 7.33e-94: 321: 21.45		RAP1B_HUMAN (3-189): 1.31e-82: 244: 26.60
+	Hs
		812875 RPGP1_HUMAN (1554-1848): 7.33e-94: 321: 21.45		RAP1A_HUMAN (3-171): 6.1e-80: 237: 26.47
+	Dm
		114693 M9PD17_DROME (1567-1849): 1.04e-65: 249: 23.81		RHEB_DROME (3-176): 1.3e-11: 62: 28.65
+	Dm
		1371386 Q9VW83_DROME (1567-1849): 1.08e-65: 249: 23.81		RHEB_DROME (3-176): 1.3e-11: 62: 28.65