HitPredict

Interactor 1: SMU1 (Q2TAY7)
WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]
Gene: SMU1

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25720964
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 707
+	Hs
		903418 WDR5_HUMAN (78-425): 2.83e-76: 245: 21.25		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Mm
		925836 LIS1_MOUSE (4-472): 4.97e-90: 283: 15.13		LIS1_MOUSE (457-706): 3e-66: 226: 27.08
+	Dm
		1358859 WDS_DROME (16-245): 4.14e-18: 87.7: 9.88		FBXW7_DROME (142-705): 3.41e-131: 421: 66.33
+	Hs
		792935 LIS1_HUMAN (4-472): 9.67e-90: 282: 15.13		LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08
+	Hs
		245633 TBL1X_HUMAN (252-512): 3.08e-62: 215: 18.38		TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58
+	Hs
		1309163 TBL1Y_HUMAN (252-512): 1.12e-61: 212: 18.02		TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58
+	Hs
		903521 WDR26_HUMAN (3-513): 2.59e-99: 314: 19.45		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		792949 LIS1_HUMAN (4-472): 9.67e-90: 282: 15.13		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903077 WDR5_HUMAN (78-425): 2.83e-76: 245: 21.25		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903349 WDR5_HUMAN (78-425): 2.83e-76: 245: 21.25		WDR5B_HUMAN (570-706): 6.06e-25: 108: 23.74
+	Hs
		903551 WDR5_HUMAN (78-425): 2.83e-76: 245: 21.25		NLE1_HUMAN (269-366): 5.18e-09: 61.2: 13.86
+	Sc
		630844 NLE1_YEAST (440-513): 1.34e-20: 96.9: 25.33		NLE1_YEAST (537-705): 1.06e-34: 140: 23.50
+	Hs
		903428 SNR40_HUMAN (18-240): 3.64e-24: 105: 10.50		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Dm
		1358845 WDS_DROME (16-245): 4.14e-18: 87.7: 9.88		WDS_DROME (570-706): 5.69e-27: 115: 23.02
+	Hs
		1346954 NLE1_HUMAN (433-513): 1.02e-23: 106: 23.46		NLE1_HUMAN (269-366): 5.18e-09: 61.2: 13.86
+	Sp
		999842 TUP12_SCHPO (4-245): 2.78e-20: 96.2: 10.98		TUP11_SCHPO (604-706): 2.18e-10: 65.8: 15.39
+	Hs
		921751 GBB2_HUMAN (187-335): 1.43e-21: 97.7: 20.81		NLE1_HUMAN (269-366): 5.18e-09: 61.2: 13.86