HitPredict

Interactor 1: Q32KD4 (Q32KD4)
Argonaute-1, isoform A (Argonaute-1, isoform C) (Argonaute-1, isoform D) (LP02696p) (SD07283p)
Gene: AGO1

Interactor 2: DCR1 (Q9VCU9)
Endoribonuclease Dcr-1 (Protein dicer-1) (EC 3.1.26.3)
Gene: Dcr-1

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.915

The method score is based on:

Property Details
Experiments 15985611, 15231716, 15918769, 19451544, 35325613
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArgoL1~PAZ, ArgoL2~PAZ, PAZ~PAZ, PAZ~Ribonuclease_3, PAZ~Piwi
Common GO terms GO:0003727 - single-stranded RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007294 - germarium-derived oocyte fate determination
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 984
Dm

1 2249
+ Dm
+ Ce
+ Ce
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+ Mm
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+ Ce
+ Hs
+ Ce
+ Ce
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+ Ce
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+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024