HitPredict

Interactor 1: LRRK1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
Gene: LRRK1

Interactor 2: BAG5 (Q9UL15)
BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)
Gene: BAG5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	24510904, 29513927, 24947832
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, protein array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2015 Hs			1 447
+	Hs
		324432 LRRK1_HUMAN (1-2015): 0: 1859: 99.60		BAG3_HUMAN (361-442): 2.06e-28: 119: 44.71
+	Mm
		1130114 LRRK2_MOUSE (47-291): 6.12e-23: 109: 13.73		BAG5_MOUSE (1-447): 0: 758: 91.28
+	Hs
		1130716 LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65		BAG5_HUMAN (1-447): 0: 752: 100.00
+	Hs
		324443 LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65		BAG3_HUMAN (361-442): 2.06e-28: 119: 44.71