HitPredict

Interactor 1: MPK1 (Q39021)
Mitogen-activated protein kinase 1 (AtMPK1) (MAP kinase 1) (EC 2.7.11.24)
Gene: MPK1

Interactor 2: MPK6 (Q39026)
Mitogen-activated protein kinase 6 (AtMPK6) (MAP kinase 6) (EC 2.7.11.24)
Gene: MPK6

Species: Arabidopsis thaliana

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.850

Property	Details
Experiments	12456655, 19095804, 19789277
Identification Methods	two hybrid, enzymatic study, pull down, protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004672 - protein kinase activity GO:0004707 - MAP kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0106310 - protein serine kinase activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 370 At			1 395
+	At
		1106523 MPK7_ARATH (1-367): 8.16e-156: 444: 81.20		MPK6_ARATH (1-395): 6.49e-168: 476: 100.00
+	At
		1106054 MPK2_ARATH (1-367): 1.49e-153: 438: 90.52		MPK6_ARATH (1-395): 6.49e-168: 476: 100.00
+	At
		1105932 MPK1_ARATH (1-370): 2.37e-160: 455: 100.00		MPK4_ARATH (29-392): 2.39e-158: 451: 69.32
+	At
		1105931 MPK1_ARATH (1-370): 2.37e-160: 455: 100.00		MPK3_ARATH (37-391): 1.37e-151: 434: 76.12
+	At
		1106290 MPK4_ARATH (16-364): 8.77e-152: 434: 55.84		MPK4_ARATH (29-392): 2.39e-158: 451: 69.32
+	At
		1105930 MPK1_ARATH (1-370): 2.37e-160: 455: 100.00		MPK2_ARATH (62-392): 9.61e-140: 404: 57.78
+	At
		1105934 MPK1_ARATH (1-370): 2.37e-160: 455: 100.00		MPK7_ARATH (62-392): 1.05e-139: 404: 55.86
+	At
		1106089 MPK2_ARATH (1-367): 1.49e-153: 438: 90.52		MPK16_ARATH (61-395): 4.26e-143: 420: 50.15
+	Hs
		647591 MK03_HUMAN (21-361): 1.1e-147: 424: 48.41		MK14_HUMAN (46-392): 1.62e-148: 426: 46.71
+	Hs
		658957 MK01_HUMAN (21-361): 7.17e-148: 423: 49.57		MK14_HUMAN (46-392): 1.62e-148: 426: 46.71
+	At
		1106053 MPK2_ARATH (1-367): 1.49e-153: 438: 90.52		MPK2_ARATH (62-392): 9.61e-140: 404: 57.78
+	Hs
		658922 MK01_HUMAN (21-361): 7.17e-148: 423: 49.57		MK07_HUMAN (19-393): 1.09e-137: 414: 46.60
+	Hs
		625115 CDK2_HUMAN (29-329): 7.66e-152: 431: 37.62		CDK2_HUMAN (60-354): 6.28e-138: 397: 35.91
+	Hs
		647474 MK03_HUMAN (21-361): 1.1e-147: 424: 48.41		MK01_HUMAN (62-394): 8.58e-140: 404: 51.78
+	Hs
		658797 MK01_HUMAN (21-361): 7.17e-148: 423: 49.57		MK01_HUMAN (62-394): 8.58e-140: 404: 51.78
+	Hs
		647471 MK03_HUMAN (21-361): 1.1e-147: 424: 48.41		MK03_HUMAN (34-395): 2e-138: 401: 46.87